Metagenomic next generation sequencing(mNGS)based diagnostics that identify mi-crobial nucleic acids in clinical samples may be a useful tool in addressing some of these challenges.Studies of mNGS in immunocompromised hosts have demonstrated that these diagnostics are capable of identifying causative organisms in a subset of patients for whom conventional testing has been negative.But the reports evaluating the diagnostic efficiency of mNGS in immunocompromised patients are limit-ed to individual patients or small retrospective studies at present.This article reviewed and analyzed the literature to provide new ideas for conducting related research on mNGS in clinical practice.
关键词
免疫功能不全/感染性疾病/病原体/宏基因组二代测序/液体活检/感染监测
Key words
immune dysfunction/infectious diseases/pathogens/metagenomic next generation sequencing/liquid biopsy/infection surveillance
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