Value of three-dimensional energy Doppler ultrasound parameters combined with placental growth factor in predicting early-onset fetal growth restriction
Objective To explore the value of three-dimensional energy Doppler ultrasound pa-rameters combined with placental growth factor(PLGF)in predicting early-onset fetal growth restric-tion(FGR).Methods Eighty pregnant women with early-onset FGR were selected as FGR group,and another 50 healthy pregnant women with prenatal examination were selected as control group.Three-dimensional energy Doppler ultrasonography was performed for all subjects at 1 1 to 13 weeks plus 6 days of gestation,and placental volume(PV),vascularization index(VI),flow index(FI)and vascularization-flow index(VFI)were collected.Serum PLGF level was measured in all subjects at 14 to 16 weeks plus 6 days of gestation.Results The PV,VI,FI,VFI and serum PLGF level in the FGR group were significantly lower than those in the control group(P＜0.05).Multiple Logistic regression analysis showed that low PV,VI,FI and VFI as well as serum PLGF level were risk factors for early-onset FGR(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that PV,VI,VFI and serum PLGF had certain predictive value for early-onset FGR,with areas under the curve of 0.723(95％CI,0.629 to 0.817),0.776(95％CI,0.693 to 0.860),0.746(95％CI,0.653 to 0.839)and 0.799(95％CI,0.713 to 0.884)respectively.The predictive value of FI for early-onset FGR was moderate,with an area under the curve of 0.625(95％CI,0.524 to 0.725).Analysis showed that the combination of PLGF and VI as well as PLGF and VFI had good predictive values for early-onset FGR,the sensitivity,specificity and Youden index of PLGF combined with VI were 86.25％,76.00％and 0.623 respectively,while those of PLGF combined with VFI were 81.25％,80.00％and 0.613 respectively.Conclusion The combination of three-dimensional en-ergy Doppler ultrasound parameters and PLGF has certain predictive value for early-onset FGR,and can be used for clinical screening of high-risk populations with early-onset FGR.
fetal growth restrictionthree-dimensional energy Doppler ultrasoundplacental growth factorpredictive value
万方数据
维普
