术前血清V-set和免疫球蛋白结构域4以及长链非编码核糖核酸SBF2反义RNA1与肾结石患者经皮肾镜取石术后急性肾损伤的关系

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中文摘要：目的探讨术前血清V-set和免疫球蛋白结构域4(VSIG4)以及长链非编码核糖核酸(LncRNA)SBF2反义RNA1(SBF2-AS1)与肾结石患者经皮肾镜取石术后急性肾损伤(AKI)的关系。方法选择2020年1月-2022年12月本院收治的109例肾结石患者为研究对象。术前检测患者血清VSIG4水平以及LncRNA SBF2-AS1表达，术后记录AKI发生情况。采用多因素Logistic回归模型分析肾结石患者经皮肾镜取石术后发生AKI的影响因素;采用受试者工作特征(ROC)曲线分析VSIG4、LncRNA SBF2-AS1预测肾结石患者经皮肾镜取石术后发生AKI的价值。结果本研究中，术后发生AKI者16例。AKI组血清VSIG4水平低于非AKI组，LncRNA SBF2-AS1表达高于非AKI组，差异均有统计学意义(P＜0。05)。多因素Logistic回归分析显示，术前高尿酸水平、术前高LncRNA SBF2-AS1表达、较长的手术时间、术中低血压是肾结石患者经皮肾镜取石术后发生AKI的危险因素(P＜0。05)，术前高VSIG4水平是保护因素(P＜0。05)。术前血清VSIG4、LncRNA SBF2-AS1水平预测肾结石患者经皮肾镜术后发生AKI的曲线下面积分别为0。854、0。705，二者联合预测的曲线下面积为0。948，大于各指标单独预测(Z=1。995、2。958，P＜0。05)。结论肾结石患者术前血清VSIG4水平降低、LncRNA SBF2-AS1表达增高与经皮肾镜取石术后AKI的发生有关，联合检测术前VSIG4、LncRNA SBF2-AS1可预测术后AKI的发生风险。

外文标题：Correlations of preoperative serum V-set and immunoglobulin domain 4 and long chain non-coding ribonucleic acid SBF2-antisense RNA1 with acute kidney injury after percutaneous nephrolithotomy in patients with renal calculus

外文摘要：Objective To investigate the relationships of preoperative serum V-set and immuno-globulin domain 4(VSIG4)and long chain non-coding ribonucleic acid(LncRNA)SBF2 antisense RNA1(SBF2-AS1)with acute kidneyinjury(AKI)after percutaneous nephrolithotomy in patients with renal calculus.Methods A total of 109 patients with renal calculus in the hospital from January 2020 to December 2022 were selected as research objects.Serum VSIG4 level and LncRNA SBF2-AS1 expression were detected in all the patients before operation,and incidence of AKI was recorded after operation.Multiple Logistic regression model was used to analyze the factors affecting AKI after percutaneous nephrolithotomy in patients with renal calculus;the receiver operating characteristic(ROC)curve was used to analyze the values of VSIG4 and LncRNA SBF2-AS1 in predicting AKI af-ter percutaneous nephrolithotomy in patients with renal calculus.Results In this study,16 cases had AKI after operation.The serum VSIG4 level in the AKI group was significantly lower than that in the non-AKI group,while the LncRNA SBF2-AS1 expression was significantly higher than that in the non-AKI group(P＜0.05).Multivariate Logistic regression analysis showed that preoperative high level of uric acid,preoperative high expression of LncRNA SBF2-AS1,the longer operation time and intraoperative hypotension were the risk factors for AKI after percutaneous nephrolithotomy in pa-tients with renal calculus(P＜0.05),while preoperative high level of VSIG4 was the protective factor(P＜0.05).The values of area under the curve of preoperative serum VSIG4 and LncRNA SBF2-AS1 in predicting AKI after percutaneous nephrolithotomy in patients with renal calculus were 0.854 and 0.705 respectively,and the area under the curve of combined prediction of the two inde-xes was 0.948,which was significantly higher than that of single index prediction(Z=1.995,2.958,P＜0.05).Conclusion Decreased preoperative serum VSIG4 level and increased expres-sion of LncRNA SBF2-AS1 in patients with renal calculus are associated with the occurrence of AKI after percutaneous nephrolithotomy,and the combined detection of preoperative VSIG4 and LncRNA SBF2-AS1 can predict the risk of AKI after operation.

外文关键词：

renal calculuspercutaneous nephrolithotomyacute kidney injuryV-set and immunoglobulin domain 4long chain non-coding ribonucleic acidSBF2 antisense RNA1

作者：

姚俊波、贾波、刘加元、邹一鸣、邓思文

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作者单位：

湖北省武汉市东西湖区人民医院泌尿外科,湖北武汉,430040

关键词：

肾结石经皮肾镜取石术急性肾损伤 V-set和免疫球蛋白结构域4 长链非编码核糖核酸 SBF2反义RNA1

基金：

湖北省卫生健康委科研项目湖北省武汉市医学科研项目

项目编号：

WJ2019F064WZ20B03

出版年：

2024

DOI：

10.7619/jcmp.20234050

实用临床医药杂志

扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD

影响因子：1.543

ISSN：1672-2353

年,卷(期)：2024.28(10)

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