摘要
目的 探讨体细胞质量指数(BCMI)在维持性血液透析(MHD)患者合并肌少症中的诊断价值.方法 选取92例MHD患者为研究对象.根据MHD患者是否合并肌少症分为肌少症组(n=25)与非肌少症组(n=67).比较2组患者的基线资料.分析MHD患者发生肌少症的影响因素.绘制受试者工作特征(ROC)曲线评估BCMI对肌少症的诊断价值.结果 肌少症组的骨骼肌质量指数(SMI)、BCMI、体质量指数(BMI)、上臂肌肉围度(AMC)、腰围(WC)、体细胞质量(BCM)、相位角(PhA)、细胞外水分(ECW)、细胞总水分(TBW)、总白蛋白、前白蛋白、白蛋白、肌酐和血清磷低于非肌少症组,年龄大于非肌少症组,差异有统计学意义(P＜0.05).单因素Logistic回归分析显示,BCMI、白蛋白、年龄、BMI、SMI、ECW、TBW、PhA、AMC、WC、肌酐、血清磷均是肌少症的影响因素(P＜0.05);多因素Logistic回归分析显示,BCMI是肌少症的独立影响因素(P＜0.05).BCMI诊断肌少症的ROC曲线的曲线下面积(AUC)为0.818.结论 BCMI可作为诊断MHD患者合并肌少症的敏感指标,其可用于识别MHD合并肌少症的高危人群.
Abstract
Objective To investigate the diagnostic value of the body cell mass index(BCMI)in maintenance hemodialysis(MHD)patients with sarcopenia.Methods A total of 92 MHD patients were selected as the research subjects.They were divided into sarcopenia group(n=25)and non-sar-copenia group(n=67)based on whether they had sarcopenia.The baseline data of the two groups were compared,and the influencing factors of sarcopenia in MHD patients were analyzed.A receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of BCMI for sarcope-nia.Results The skeletal muscle mass index(SMI),BCMI,body mass index(BMI),arm muscle circumference(AMC),waist circumference(WC),body cell mass(BCM),phase angle(PhA),extracellular water(ECW),total body water(TBW),total albumin,prealbumin,albumin,creati-nine and serum phosphorus in the sarcopenia group were significantly lower,and age in the sarcopenia group was significantly higher than that in the non-sarcopenia group(P＜0.05).Univariate Logistic regression analysis showed that BCMI,albumin,age,BMI,SMI,ECW,TBW,PhA,AMC,WC,creatinine and serum phosphorus were all influencing factors of sarcopenia(P＜0.05);multivariate Logistic regression analysis showed that BCMI was an independent influencing factor of sarcopenia(P＜0.05).The area under the curve(AUC)of ROC curve for BCMI in diagnosing sarcopenia was 0.818.Conclusion BCMI can serve as a sensitive indicator for diagnosing sarcopenia in MHD pa-tients and can be used to identify high-risk populations of MHD patients with sarcopenia.
基金项目
扬州市科技计划(YZ2022102)
扬州大学医学创新转化专项临床转化研究项目(AHYZUZHXM202105)
维普
万方数据