摘要
目的 探讨多囊卵巢综合征(PCOS)患者血清中神经调节蛋白4(NRG4)水平与性激素及代谢水平的相关性.方法 选取87例PCOS患者作为研究对象(PCOS组),另选同期健康的90例女性(无生殖系统疾病,月经正常且性激素检查正常)作为对照组.采用酶联免疫吸附试验(ELISA)检测血清NRG4水平、糖脂代谢指标和性激素指标.采用Pearson法及多元线性回归分析PCOS患者血清NRG4与各指标的相关性.结果 PCOS组患者血清NRG4水平为(24.41±7.31)ng/mL,高于对照组的(15.43±4.26)ng/mL,差异有统计学意义(P＜0.001).与对照组比较,PCOS组患者BMI、超敏C反应蛋白(hs-CRP)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、黄体生成素(LH)、黄体生成素/卵泡刺激激素(LH/FSH)、泌乳素及总睾酮水平升高,差异有统计学意义(P＜0.05).PCOS患者血清NRG4水平与BMI、hs-CRP、FBG、FINS、HOMA-IR、TG、LH、LH/FSH、总睾酮呈正相关(P＜0.05);BMI、FBG、TG 是血清 NRG4 水平的影响因素(P＜0.05).结论 PCOS患者血清NRG4水平升高与糖脂代谢和性激素指标异常相关.
Abstract
Objective To investigate the correlations of serum neuregulin 4(NRG4)level with sex hormone and metabolism level in patients with polycystic ovary syndrome(PCOS).Methods A total of 87 PCOS patients were selected as the study subjects(PCOS group),and 90 healthy women(no reproductive system diseases,normal menstruation and normal sex hormone examination)were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect ser-um NRG4 level,glucose and lipid metabolism indexes and sex hormone indexes.Pearson method and multiple linear regression were used to analyze the correlation between serum NRG4 and various inde-xes in PCOS patients.Results The serum NRG4 level in PCOS group was(24.41±7.31)ng/mL,which was significantly higher than(15.43±4.26)ng/mL in the control group(P＜0.001).Com-pared with the control group,the levels of BMI,hypersensitive C-reactive protein(hs-CRP),fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR),triglyceride(TG),luteinizing hormone(LH),luteinizing hormone/follicle stimulating hormone(LH/FSH),prolactin and total testosterone in PCOS group were significantly increased(P＜0.05).Serum NRG4 levels in PCOS patients were positively correlated with BMI,hs-CRP,FBG,FINS,HOMA-IR,TG,LH,LH/FSH and total testosterone(P＜0.05);the BMI,FBG and TG were the influencing factors of serum NRG4 level(P＜0.05).Conclusion The increase of serum NRG4 level in PCOS patients is associated with abnormal glucose and lipid metabolism and sex hormone indexes.
基金项目
江苏省妇幼健康科研项目(2018)(F201843)
苏州市科技发作计划(第二十九批)(2020)(SYS2020053)
张家港卫生人才培养项目(2020)(ZJGWSRC202007)
张家港科技计划立项项目(2019)(ZKS1920)
维普
万方数据