摘要
目的 研究给药流程对多发性骨髓瘤化疗患者舒适度、耐受性和不良事件的影响.方法 选取多发性骨髓瘤化疗患者113例,随机分为对照组56例和观察组57例,对照组采用常规给药流程,观察组采用优化设计的给药流程行硼替佐米皮下注射.比较2组患者干预前后的舒适度、耐受性、不良事件及注射满意率.结果 干预后观察组舒适状况量表(GCQ)生理(24.59±2.73)分、心理(25.64±2.29)分、社会文化(22.64±2.05)分、环境(11.79±1.37)分及总分(79.21±6.81)分别高于对照组的(21.68±2.67)分、(22.05±2.16)分、(18.11±1.74)分、(9.42±1.46)分及(63.52±6.34)分;观察组化疗总疗程(6.02±1.08)个,少于对照组的(7.86±1.59)个,化疗中断率8.77％低于对照组的37.5％,足量足周期同步化疗率96.49％高于对照组的82.14％;观察组给药期间不良事件(肝肾功能损伤、血小板减少症及周围神经病变)总发生率3.51％低于对照组的16.07％;观察组注射满意率为94.74％,高于对照组的78.57％;2组各项指标比较差异均有统计学意义(P＜0.05).结论 给药流程优化有利于提升多发性骨髓瘤化疗患者的舒适度和耐受性,减少不良反应的发生,且注射满意率高.
Abstract
Objective To investigate the impacts of drug administration processes on comfort,tolerability and adverse events in patients with chemotherapy for multiple myeloma.Methods A total of 113 patients with chemotherapy for multiple myeloma were randomly divided into control group(n=56)and observation group(n=57).The control group was treated with conventional drug administra-tion procedures,while the observation group was treated with bortezomib subcutaneously by an opti-mized drug administration process.Comfort level,tolerability,adverse events and satisfaction rate for injection were compared between the two groups before and after intervention.Results After interven-tion,the observation group scored higher on the General Comfort Questionnaire(GCQ)for physiologi-cal dimension of(24.59±2.73),psychological dimension of(25.64±2.29),sociocultural dimen-sion of(22.64±2.05),environmental of(11.79±1.37),and total score of(79.21±6.81)than(21.68±2.67),(22.05±2.16),(18.11±1.74),(9.42±1.46)and(63.52±6.34)respec-tively in the control group.Total chemotherapy course was(6.02±1.08)cycles in the observation group,which was less than(7.86±1.59)cycles in the control group,with a chemotherapy discontin-uation rate of 8.77％versus 37.5％,and the full-dose and full-schedule chemotherapy completion rate of 96.49％versus to 82.14％between observation group and control group,and all the differences were statistical significant(P＜0.05).The overall incidence of liver-kidney function damage,throm-bocytopenia,and peripheral neuropathy during medication administration was 3.51％in the observa-tion group,which was significantly lower than 16.07％in the control group(P＜0.05).The satisfac-tion rate for injection in the observation group was 94.74％,which was significantly higher than 78.57％in the control group(P＜0.05).Conclusion Optimizing the drug administration process can improve patient's comfort and tolerability during chemotherapy for multiple myeloma,reduce the incidence rate of adverse reactions,and has a high satisfaction rate for injection.
维普
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