Prevalence of frailty in patients with rheumatoid arthritis:a systematic review
Objective To systematically evaluate the prevalence of frailty in patients with rheu-matoid arthritis(RA).Methods A systematic search method for observational studies on the preva-lence of frailty in patients with RA was conducted,and literature screening,data extraction as well as evaluation of literature quality were performed in strict accordance with evidence-based medical re-search methodology.Meta-analysis and Egger's linear regression analysis were performed by Stata 16.0 software.Results Twenty-six literatures were included in the study,including a total sample size of 22,547 patients.The results of the analysis showed that the total prevalence of frailty in patients with RA was 36％(95％CI,0.26 to 0.45,P＜0.001),and the prevalence of pre-frailty was 43％(95％CI,0.36 to 0.50,P＜0.001).The results of subgroup analysis showed that the incidence of frailty was higher in RA patients with features of female,age over 60 years old,hospitalization,living in Europe-an region and evaluation with multi-dimensional comprehensive frailty assessment tool and the specific RA frailty assessment tool.Conclusion The overall incidence of frailty and pre-frailty in RA patients is high,and there are differences in the incidence of frailty among patients with different ages,gen-ders,environments,regions,and types of assessment tools.
rheumatoid arthritisfrailtysystematic reviewevidence based medicine
万方数据
维普
