摘要
目的 系统评价类风湿关节炎(RA)患者衰弱发生率.方法 系统检索有关RA患者衰弱发生率的观察性研究,严格按照循证医学研究方法进行文献筛选、资料提取及文献质量评价.应用Stata 16.0软件进行Meta分析、Egger线性回归分析.结果 本研究共纳入26篇文献,总样本量22 547例.结果 显示,RA患者衰弱总体发生率为36％(95％CI:0.26～0.45,P＜0.001),衰弱前期总体发生率为43％(95％CI:0.36～0.50,P＜0.001).亚组分析结果显示,女性、60岁及以上、住院、欧洲地区和基于多维度综合衰弱评估工具及特异性RA衰弱评估工具评估的RA患者衰弱发生率更高.结论 RA患者衰弱及衰弱前期总体发生率均较高,且在不同年龄、性别、研究场所、区域及采用不同评估工具类型的患者中存在差异.
Abstract
Objective To systematically evaluate the prevalence of frailty in patients with rheu-matoid arthritis(RA).Methods A systematic search method for observational studies on the preva-lence of frailty in patients with RA was conducted,and literature screening,data extraction as well as evaluation of literature quality were performed in strict accordance with evidence-based medical re-search methodology.Meta-analysis and Egger's linear regression analysis were performed by Stata 16.0 software.Results Twenty-six literatures were included in the study,including a total sample size of 22,547 patients.The results of the analysis showed that the total prevalence of frailty in patients with RA was 36％(95％CI,0.26 to 0.45,P＜0.001),and the prevalence of pre-frailty was 43％(95％CI,0.36 to 0.50,P＜0.001).The results of subgroup analysis showed that the incidence of frailty was higher in RA patients with features of female,age over 60 years old,hospitalization,living in Europe-an region and evaluation with multi-dimensional comprehensive frailty assessment tool and the specific RA frailty assessment tool.Conclusion The overall incidence of frailty and pre-frailty in RA patients is high,and there are differences in the incidence of frailty among patients with different ages,gen-ders,environments,regions,and types of assessment tools.
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