Changes and significance of serum pro-gastrin-releasing peptide,squamous cell carcinoma-related antigen and carbohydrateantigen 72-4 in patients with gastric cancer
Objective To investigate the changes and clinical significance of serum pro-gastrin-releasing peptide(ProGRP),squamous cell carcinoma-related antigen(SCC),and carbohydrate an-tigen 72-4(CA72-4)levels in patients with gastric cancer.Methods A total of 68 patients with gastric cancer(gastric cancer group),37 patients with benign gastric lesions(benign gastric lesion group),and 30 healthy subjects(non-gastric disease group)were selected as the study participants.Serum ProGRP,SCC,and CA72-4 levels were compared among the three groups on admission.The relationships of serum ProGRP,SCC,and CA72-4 levels with pathological parameters were analyzed in the gastric cancer group.Patients in the gastric cancer group were followed up for 24-month after discharge.Multivariate Logistic regression analysis was used to identify the influencing factors of prog-nosis in gastric cancer patients.Receiver operating characteristic(ROC)curves were plotted and the area under the curve(AUC)was calculated to analyze the predictive value of serum ProGRP,SCC,and CA72-4 for death during follow-up in gastric cancer patients.Results The serum levels of ProGRP,SCC,and CA72-4 in the gastric cancer group were higher than those in the benign gastric lesion group and the non-gastric disease group,and the serum levels of ProGRP and CA72-4 in the benign gastric lesion group were higher than those in the non-gastric disease group(P＜0.05).In the gas-tric cancer group,patients with TNM stage Ⅲ to Ⅳ,moderately-lowly differentiated histological grade,and lymph node metastasis had higher serum levels of ProGRP and CA72-4 than those with stage Ⅰ to Ⅱ,high differentiation,and no lymph node metastasis.Patients with moderately-lowly differentiated histological grade had higher serum levels of SCC than those with high differentiated histological grade(P＜0.05).After 24 months of follow-up,49 patients survived(survival group)and 19 patients died(death group)in the gastric cancer group.The serum levels of ProGRP,SCC,and CA72-4 in the death group were higher than those in the survival group on admission(P＜0.05).Multivariate Logistic regression analysis showed that serum ProGRP,SCC,and CA72-4 were independent influencing factors for the prognosis of gastric cancer patients(P＜0.05).Serum ProGRP,SCC,and CA72-4 had good predictive efficacy for death during follow-up in gastric cancer patients(AUC=0.766,0.705,0.828),and their combined predictive efficacy was better(AUC=0.899).Conclusion The serum levels of ProGRP,SCC,and CA72-4 that are related to TNM stage,histological grade,and lymph node metastasis in patients with gastric cancer are abnormally elevated,and their combined detection has good predictive efficacy for death during follow-up.
万方数据
维普
