Effect of tegafur,gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones,matrix metalloproteinase-2 and matrix metalloproteinase-9 in elderly patients with gastric cancer
Objective To investigate the effects of tegafur,gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones,matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)in elderly patients with gastric cancer.Methods A total of 128 elderly patients with gastric cancer were selected as the study subjects and randomly divided into control group(n=64)and observation group(n=64).The control group was treated with tegafur,gimeracil and oteracil potassium,while the observation group received tegafur,gimeracil and oteracil potassium combined with oxaliplatin.Gastric motility-related hormones[motilin(MTL)and vasoac-tive intestinal peptide(VIP)],MMP-2,MMP-9,tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)],clinical ef-ficacy and occurrence of adverse reactions were observed in both groups.The correlations of gastric motility-related hormones with the levels of MMP-2,MMP-9 and tumor markers were analyzed.Re-sults After treatment,MTL levels in both groups were significantly lower,while VIP levels were signifi-cantly higher compared to before treatment.Additionally,the observation group had significantly lower MTL and higher VIP levels compared to the control group(P＜0.05).After treatment,the levels of MMP-2,MMP-9,CEA,CA125 and CA19-9 were significantly reduced in both groups compared to pretreatment levels,with the observation group showing significantly lower levels than the control group(P＜0.05).The total effective rate in the observation group was 70.31％,which was signifi-cantly higher than the 53.13％in the control group(P＜0.05).There was no statistically signifi-cant difference in the incidence of adverse reactions between the two groups(P＞0.05).A negative correlation was observed between MTL and MMP-2,MMP-9,CEA,CA125 as well as CA19-9(P＜0.05),while VIP showed a positive correlation with MMP-2,MMP-9,CEA,CA125 and CA19-9(P＜0.05).Conclusion The combination of tegafur,gimeracil and oteracil potassium and oxali-platin is effective and safe for the treatment of elderly patients with gastric cancer.MTL,VIP,MMP-2,MMP-9,CEA,CA125 and CA19-9 are interrelated in the development of gastric cancer in elderly patients.
tegafur,gimeracil and oteracil potassiumoxaliplatinelderly patients with gas-tric cancergastric motility-related hormonesmatrix metalloproteinase-2matrix metalloproteinase-9
万方数据
维普
