实用临床医药杂志2024，Vol.28Issue(12) ：72-76.DOI:10.7619/jcmp.20240664

血清脱嘌呤脱嘧啶核酸内切酶1自身抗体、生长分化因子15水平对结直肠癌患者术后复发转移的预测价值

Predictive value of serum apurinic/apyrimidinic endonuclease 1 autoantibodies and growth differentiation factor 15 levels for post-surgical recurrence and metastasis in patients with colorectal cancer

沈磊 刘志宁 杨金珠 宋琪
实用临床医药杂志2024，Vol.28Issue(12) ：72-76.DOI:10.7619/jcmp.20240664
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血清脱嘌呤脱嘧啶核酸内切酶1自身抗体、生长分化因子15水平对结直肠癌患者术后复发转移的预测价值

Predictive value of serum apurinic/apyrimidinic endonuclease 1 autoantibodies and growth differentiation factor 15 levels for post-surgical recurrence and metastasis in patients with colorectal cancer

沈磊 1刘志宁 2杨金珠 1宋琪1
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作者信息

  • 1. 安徽省合肥市第三人民医院/安徽医科大学合肥第三临床学院肿瘤科,安徽合肥,230051
  • 2. 安徽医科大学第二附属医院普外科,安徽合肥,230011
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摘要

目的 分析血清脱嘌呤脱嘧啶核酸内切酶1自身抗体(APE1-AAbs)、生长分化因子15(GDF-15)水平及对结直肠癌患者术后复发转移的预测价值.方法 选取52例结直肠癌患者为观察组,并根据预后情况分为术后复发转移组(n=15)和术后未复发转移组(n=37).选取同期正常体检健康者52例为对照组.检测APE1-AAbs、GDF-15水平.采用Pearson相关性分析法分析APE1-AAbs、GDF-15与结直肠癌术后复发转移的相关性.绘制受试者工作特征(ROC)曲线分析APE1-AAbs、GDF-15对结直肠癌术后复发转移的预测价值.结果 观察组的APE1-AAbs、GDF-15水平高于对照组,差异有统计学意义(P＜0.05).术后复发转移组的APE1-AAbs、GDF-15水平高于术后未复发转移组,差异有统计学意义(P＜0.05).APE1-AAbs、GDF-15水平与结直肠癌术后复发转移呈正相关(P＜0.05).APE1-AAbs、GDF-15联合预测结直肠癌术后复发转移的价值高于APE1-AAbs、GDF-15单独预测,差异有统计学意义(P＜0.05).结论 APE1-AAbs、GDF-15在结直肠癌患者血清中呈高表达.APE1-AAbs、GDF-15或可作为结直肠癌术后复发转移的标志物.

Abstract

Objective To analyze the serum levels of apurinic/apyrimidinic endonuclease 1 au-toantibodies(APE1-AAbs)and growth differentiation factor 15(GDF-15)and their predictive value for postoperative recurrence and metastasis in patients with colorectal cancer.Methods Fifty-two pa-tients with colorectal cancer were selected as observation group,and were divided into postoperative re-currence and metastasis group(n=15)and non-recurrence and metastasis group(n=37)according to prognosis.Fifty-two healthy individuals undergoing routine physical examination during the same pe-riod were selected as the control group.The levels of APE1-AAbs and GDF-15 were measured.Pear-son correlation analysis was used to analyze the correlations of APE1-AAbs,GDF-15 with post-surgical recurrence and metastasis of colorectal cancer.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of APE1-AAbs and GDF-15 for post-surgical recurrence and metastasis of colorectal cancer.Results The levels of APE1-AAbs and GDF-15 in the observation group were significantly higher than those in the control group(P＜0.05).The levels of APE1-AAbs and GDF-15 in the postoperative recurrence and metastasis group were significantly higher than those in the non-recurrence and metastasis group(P＜0.05).There was a positive correlation between the levels of APE1-AAbs,GDF-15 and post-surgical recurrence and metastasis of colorectal cancer(P＜0.05).The combined use of APE1-AAbs and GDF-15 had higher predictive value for post-surgical recurrence and metastasis of colorectal cancer than either single prediction(P＜0.05).Conclusion APE1-AAbs and GDF-15 are highly expressed in the serum of colorectal cancer patients.APE1-AAbs and GDF-15 may serve as markers for post-surgical recurrence and metastasis of colorectal cancer.

关键词

结直肠癌/脱嘌呤脱嘧啶核酸内切酶1自身抗体/生长分化因子15/术后复发转移

Key words

colorectal cancer/apurinic/apyrimidinic endonuclease 1 autoantibodies/growth differentiation factor 15/recurrence and metastasis after surgery

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基金项目

安徽省教育厅高校科学研究重点项目(KJ2021A0317)

安徽省合肥市卫健委应用医学研究项目(Hwk2023zc013)

出版年

2024
实用临床医药杂志
扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD
影响因子：1.543
ISSN：1672-2353
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