Predictive value of serum apurinic/apyrimidinic endonuclease 1 autoantibodies and growth differentiation factor 15 levels for post-surgical recurrence and metastasis in patients with colorectal cancer
Objective To analyze the serum levels of apurinic/apyrimidinic endonuclease 1 au-toantibodies(APE1-AAbs)and growth differentiation factor 15(GDF-15)and their predictive value for postoperative recurrence and metastasis in patients with colorectal cancer.Methods Fifty-two pa-tients with colorectal cancer were selected as observation group,and were divided into postoperative re-currence and metastasis group(n=15)and non-recurrence and metastasis group(n=37)according to prognosis.Fifty-two healthy individuals undergoing routine physical examination during the same pe-riod were selected as the control group.The levels of APE1-AAbs and GDF-15 were measured.Pear-son correlation analysis was used to analyze the correlations of APE1-AAbs,GDF-15 with post-surgical recurrence and metastasis of colorectal cancer.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of APE1-AAbs and GDF-15 for post-surgical recurrence and metastasis of colorectal cancer.Results The levels of APE1-AAbs and GDF-15 in the observation group were significantly higher than those in the control group(P＜0.05).The levels of APE1-AAbs and GDF-15 in the postoperative recurrence and metastasis group were significantly higher than those in the non-recurrence and metastasis group(P＜0.05).There was a positive correlation between the levels of APE1-AAbs,GDF-15 and post-surgical recurrence and metastasis of colorectal cancer(P＜0.05).The combined use of APE1-AAbs and GDF-15 had higher predictive value for post-surgical recurrence and metastasis of colorectal cancer than either single prediction(P＜0.05).Conclusion APE1-AAbs and GDF-15 are highly expressed in the serum of colorectal cancer patients.APE1-AAbs and GDF-15 may serve as markers for post-surgical recurrence and metastasis of colorectal cancer.
colorectal cancerapurinic/apyrimidinic endonuclease 1 autoantibodiesgrowth differentiation factor 15recurrence and metastasis after surgery
万方数据
维普
