Value of serum microRNA-184 and microRNA-451a expression in predicting recurrent metastasis after radical surgery of patients with non-small cell lung cancer in stage Ⅰ to Ⅱ A
Objective To investigate the value of serum microRNA(miRNA)-184 and miR-451a expression in predicting recurrent metastasis after radical resection of stage Ⅰ to Ⅱ A non-small cell lung cancer(NSCLC).Methods A total of 203 patients with radical resection of stage Ⅰ to Ⅱ A NSCLC in the hospital from January 2020 to October 2021 were selected as NSCLC group.According to the recurrence and metastasis status during the 2-year follow-up,they were divided into recurrence and metastasis group with 30 cases and non-recurrence and metastasis group with 173 cases.Addition-ally,87 healthy volunteers with physical examinations in the same period were selected as control group.Real-time quantitative polymerase chain reaction was used to detect serum expression of miR-184 and miR-451a.Multivariate Logistic regression model was used to analyze the factors affecting recurrence and metastasis after radical resection of stage Ⅰ to Ⅱ A NSCLC.Receiver operating characteristic(ROC)curve was used to analyze the value of serum miR-184 and miR-451 a expression in predicting recurrence and metastasis.Results Compared with the control group,the expression of serum miR-184 and miR-451a in the NSCLC group decreased significantly(P＜0.05).After 2 years of follow-up,the recurrence and metastasis rate of 203 patients with stage Ⅰ to ⅡA NSCLC was 14.78％(30/203).Compared with the non-recurrence and metastasis group,the expression of serum miR-184 and miR-451a in the recurrence and metastasis group decreased significantly(P＜0.05).The independent risk factors for recurrence and metastasis after radical resection of stage Ⅰ to Ⅱ A NSCLC were stage Ⅱ A,poor differentiation and postoperative adjuvant chemotherapy,while the independent protective factors were increased miR-184 and miR-451a expression(P＜0.05).The area under the curve(AUC)of the combined prediction of serum miR-184 and miR-45 1 a expression for recurrence and metastasis after radical resection of stage Ⅰ to Ⅱ A NSCLC was 0.868,which was greater than 0.784 and 0.781 of serum miR-184 and miR-451 a expression alone(P＜0.05).Conclusion The serum miR-184 and miR-451a expression in patients with stage Ⅰ to ⅡA NSCLC is low and closely re-lated to recurrence and metastasis after radical resection.The combined detection of serum miR-184 and miR-451a has a high predictive value for recurrence and metastasis after radical resection of stage Ⅰ to ⅡA NSCLC.
non-small cell lung cancerradical resectionmicroRNA-184microRNA-451arecurrence and metastasis
万方数据
维普
