重复经颅磁刺激对精神分裂症患者迟发性运动障碍的干预效果

Interventional effect of repetitive transcranial magnetic stimulation on tardive dyskinesia in schizophrenic patients

刘亚丽 ¹李克松 ¹靳红强 ¹崔月 ¹王小方 ¹刘雅 ¹高玉 ¹陈运昭¹

扫码查看

作者信息

1. 河北省第三荣军优抚医院,河北保定,071000
折叠

摘要

目的探讨重复经颅磁刺激(rTMS)对精神分裂症患者迟发性运动障碍(TD)的干预效果.方法选取105例精神分裂症患者为研究对象,随机分为1 Hz治疗组、10Hz治疗组和对照组,每组35例.3组均给予rTMS治疗12周.比较3组的不自主运动评定量表(AIMS)、负性症状量表(SANS)、阳性和负性症状量表(PANSS)和治疗副反应量表(TESS)评分.检测患者的心电图、血常规、血生化、激素水平等生理指标.结果治疗后,1 Hz治疗组和10 Hz治疗组的AIMS总分低于治疗前,且1 Hz治疗组和10 Hz治疗组低于对照组,差异有统计学意义(P＜0.05).1 Hz治疗组和10 Hz治疗组的AIMS减分率分别为68.6％和65.7％,高于对照组的22.9％,差异有统计学意义(P＜0.05).治疗后,1 Hz治疗组和10 Hz治疗组的SANS总分、PANSS总分低于治疗前,且1 Hz治疗组和10 Hz治疗组低于对照组,差异有统计学意义(P＜0.05).1 Hz治疗组和10 Hz治疗组的AIMS总分、疗效、PANSS总分比较,差异无统计学意义(P＞0.05).3组治疗前后的TESS总分和生理指标比较,差异无统计学意义(P＞0.05).结论 1 Hz和10 Hz的rTMS均能有效改善精神分裂症患者的TD,且安全性良好,无明显副反应和生理损害.

Abstract

Objective To explore the interventional effect of repetitive transcranial magnetic stimulation(rTMS)on tardive dyskinesia(TD)in schizophrenic patients.Methods A total of 105 schizophrenic patients were selected as subjects and randomly divided into 1 Hz treatment group,10 Hz treatment group and control group,with 35 patients in each group.All three groups received rTMS treatment for 12 weeks.The Abnormal Involuntary Movement Scale(AIMS),Scale for the As-sessment of Negative Symptoms(SANS),Positive and Negative Syndrome Scale(PANSS)and Treat-ment Emergent Symptom Scale(TESS)scores were compared among the three groups.Physiological indicators such as electrocardiogram,blood routine,blood biochemistry and hormone levels were mo-nitored.Results After treatment,the total AIMS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment,and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group(P＜0.05).The reduction rates of AIMS scores in the 1 Hz and 10 Hz treatment groups were 68.6％and 65.7％,respectively,which were significantly higher than the 22.9％in the control group(P＜0.05).After treatment,the total SANS and PANSS scores in the 1 Hz and 10 Hz treatment groups were significantly lower than before treatment,and those in the 1 Hz and 10 Hz treatment groups were significantly lower than those in the control group(P＜0.05).There was no statistically significant difference in the total AIMS score,efficacy and total PANSS score between the 1 Hz and 10 Hz treatment groups(P＞0.05).There were no significant differences in the total TESS scores and physiological indicators among the three groups before and after treatment(P＞0.05).Conclusion Both 1 Hz and 10 Hz rTMS can effectively improve TD in schizophrenic patients with good safety and have no significant side effects or physiological damage.

关键词

重复经颅磁刺激/迟发性运动障碍/精神分裂症/干预模式/疗效

Key words

repetitive transcranial magnetic stimulation/tardive dyskinesia/schizophrenia/intervention mode/curative effect

引用本文复制引用

基金项目

河北省保定市科技计划项目(2211ZF004)

出版年

2024

实用临床医药杂志

扬州大学,中国高校科技期刊研究会

实用临床医药杂志

CSTPCD

影响因子：1.543

ISSN：1672-2353

参考文献量10

段落导航