Distribution of pulmonary infection pathogens after lung cancer chemotherapy and diagnostic values of serum cytokeratin 19 fragment antigen,high mobility group box 1 protein and soluble hemoglobin scavenger receptor
Distribution of pulmonary infection pathogens after lung cancer chemotherapy and diagnostic values of serum cytokeratin 19 fragment antigen,high mobility group box 1 protein and soluble hemoglobin scavenger receptor
Objective To investigate the distribution of pathogens causing pulmonary infection af-ter lung cancer chemotherapy and the changes and diagnostic value of serum cytokeratin 19 fragment antigen(CYFRA21-1),high mobility group box 1 protein(HMGB1),and soluble hemoglobin scav-enger receptor(sCD163)levels.Methods A total of 83 lung cancer patients with chemotherapy from July 2022 to November 2023 were divided into non-infected group(n=43)and infected group(n=40)based on their pulmonary infection status,sputum samples were collected from lung cancer chemo-therapy patients,and the source of the samples was recorded for bacterial identification.The changes in serum CYFRA21-1,HMGB1 and sCD163 levels were compared between the two groups;a multiva-riate Logistic regression model was used to analyze the factors influencing pulmonary infection after lung cancer chemotherapy;the diagnostic values of serum CYFRA21-1,HMGB1 and sCD163 levels for pulmonary infection after lung cancer chemotherapy were analyzed.Results Among the 83 patients with lung cancer chemotherapy,40 cases had pulmonary infections;a total of 55 strains of pathogens were detected,including 34 Gram-negative bacteria and 18 Gram-positive bacteria,accounting for 61.82％and 32.73％respectively,while only 3 strains of fungi were detected,accounting for 5.45％.Serum levels of CYFRA21-1,HMGB1 and sCD163 in the infected group were significantly higher than those in the non-infected group(P＜0.05).Age,history of lung diseases,CYFRA21-1,HMGB1 and sCD163 were factors influencing pulmonary infection in patients with lung cancer chem-otherapy(P＜0.05).The areas under the curve for the diagnostic value of serum CYFRA21-1,sCD163 and HMGB1 levels for pulmonary infection after lung cancer chemotherapy were 0.677,0.763 and 0.819,respectively(P＜0.05).Conclusion The main pathogens causing pulmonary infection after lung cancer chemotherapy are Gram-negative bacteria,and the serum levels of CYFRA21-1,HMGB1 and sCD163 increase significantly,which can be used as biological indicators for early diagnosis and assessment of infection.
关键词
肺癌/化疗/肺部感染/病原菌/细胞角蛋白19片段抗原/高迁移率族蛋白B1/可溶性血红蛋白清道夫受体
Key words
lung cancer/chemotherapy/pulmonary infection/pathogens/cytokeratin 19 fragment antigen/high mobility group box 1 protein/soluble hemoglobin scavenger receptor
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