Objective To observe the clinical efficacy of azithromycin combined with acetylcys-teine alveolar lavage in the treatment of severe Mycoplasma pneumoniae pneumonia(SMPP)in chil-dren.Methods A total of 80 children with SMPP were selected as study subjects and divided into control group and observation group using a random number table method,with 40 cases in each group.The control group was treated with intravenous drip of azithromycin injection and other general symptomatic treatments for 5 days.The observation group was treated with acetylcysteine alveolar lav-age on the basis of the control group for 5 days.The clinical efficacy,laboratory indicators,and lung function indicators of the two groups were compared.Results After 5 days of treatment,the total ef-fective rate of treatment in the observation group was higher than that in the control group(P＜0.05).The duration of fever and lung moist rales in the observation group was shorter than that in the control group(P＜0.05).After 5 days of treatment,the tidal volume per kilogram of body mass(VT/kg),peak expiratory flow to peak expiratory time ratio(PTEF/TPTEF),forced expiratory flow at 25％residual tidal volume(FEF25％),and expiratory flow to peak expiratory flow ratio at 25％residual tidal volume(25/PF)of the two groups were higher than those before treatment,and VT/kg,PTEF/TPTEF,FEF25％,and 25/PF in the observation group were higher than those in the control group(P＜0.05).Conclusion Azithromycin combined with acetylcysteine alveolar lavage can effectively improve the clinical efficacy of children with SMPP,shorten the duration of fever and lung moist rales,and improve lung function.
关键词
重症肺炎支原体肺炎/乙酰半胱氨酸肺泡灌洗术/阿奇霉素/呼吸功能
Key words
severe Mycoplasma pneumoniae pneumonia/acetylcysteine alveolar lavage/az-ithromycin/respiratory function
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