Efficacy of azithromycin combined with acetylcysteine alveolar lavage in the treatment of severe Mycoplasma pneumoniae pneumonia in children
Objective To observe the clinical efficacy of azithromycin combined with acetylcys-teine alveolar lavage in the treatment of severe Mycoplasma pneumoniae pneumonia(SMPP)in chil-dren.Methods A total of 80 children with SMPP were selected as study subjects and divided into control group and observation group using a random number table method,with 40 cases in each group.The control group was treated with intravenous drip of azithromycin injection and other general symptomatic treatments for 5 days.The observation group was treated with acetylcysteine alveolar lav-age on the basis of the control group for 5 days.The clinical efficacy,laboratory indicators,and lung function indicators of the two groups were compared.Results After 5 days of treatment,the total ef-fective rate of treatment in the observation group was higher than that in the control group(P＜0.05).The duration of fever and lung moist rales in the observation group was shorter than that in the control group(P＜0.05).After 5 days of treatment,the tidal volume per kilogram of body mass(VT/kg),peak expiratory flow to peak expiratory time ratio(PTEF/TPTEF),forced expiratory flow at 25％residual tidal volume(FEF25％),and expiratory flow to peak expiratory flow ratio at 25％residual tidal volume(25/PF)of the two groups were higher than those before treatment,and VT/kg,PTEF/TPTEF,FEF25％,and 25/PF in the observation group were higher than those in the control group(P＜0.05).Conclusion Azithromycin combined with acetylcysteine alveolar lavage can effectively improve the clinical efficacy of children with SMPP,shorten the duration of fever and lung moist rales,and improve lung function.
severe Mycoplasma pneumoniae pneumoniaacetylcysteine alveolar lavageaz-ithromycinrespiratory function
万方数据
维普
