Objective To explore the clinical effect and mechanism of Xianhecao-Baizhu in treat-ment of diarrhea irritable bowel syndrome with spleen deficiency and dampness type.Methods A total of 120 patients were randomly divided into treatment group and control group,with 60 cases in each group.The treatment group was given Xianhecao-Baizhu Decoction orally,and the control group was given pefican combined with montmorillonite powder orally.The course of treatment lasted for 1 month.The improvement of main symptoms,comprehensive efficacy,serum levels of 5-HT and IL-1 βbefore and after treatment in two groups were observed.Results The improvement rate of abdominal distension or abdominal pain in the treatment group was higher than that in the control group(P＜0.05).The total effective rate of the treatment group was higher than that of the control group(P＜0.05).After treatment,serum 5-hydroxytryptamine(5-HT)and interleukin-1 β(IL-1 β)levels were decreased in both groups,but the decrease was more obvious in the treatment group than in the con-trol group(P＜0.05).After treatment,abdominal pain scores and diarrhea scores in the two groups decreased,and the decrease in the treatment group was more obvious than that in the control group(P＜0.05).The scores of Hamilton Anxiety Scale(HAMA)and IBS Quality of Life Scale(IBS-QOL)in the two groups after treatment were decreased compared with those before treatment,and the HAMA and IBS-QOL scores in the treatment group were lower than those in the control group(P＜0.01).Conclusion Xianhecao-Baizhu can treat diarrhea irritable bowel syndrome with spleen de-ficiency and dampness type by reducing the secretion levels of 5-HT and IL-1 β.
关键词
仙鹤草/白术/腹泻型肠易激综合征/5-羟色胺/白细胞介素-1β/汉密尔顿焦虑量表/生活质量量表
Key words
Xianhecao/Baizhu/diarrhea irritable bowel syndrome/5-hydroxytryptamine/interleukin-1 β/Hamilton Anxiety Scale/Quality of Life Scale
维普
万方数据