Predictive value of white blood cell-to-hematocrit ratio for in-hospital major adverse cardiovascular events after reperfusion therapy in patients with acute ST-segment elevation myocardial infarction
Objective To investigate the predictive value of white blood cell-to-hematocrit ratio(WBCHR)for in-hospital major adverse cardiovascular events(MACE)after reperfusion therapy in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A case-control study was conducted to retrospectively select 319 patients with first-time diagnosis of STEMI who un-derwent percutaneous coronary intervention(PCI).Patients were divided into MACE group(69 ca-ses)and non-MACE group(250 cases)based on the occurrence of MACE during hospitalization.Clinical data,including general information,laboratory test indicators,echocardiography,and coro-nary angiography results,were compared between the two groups.Univariate and multivariate Logistic regression analyses were performed to explore the risk factors for in-hospital MACE after reperfusion therapy in STEMI patients.Receiver operating characteristic(ROC)curve analysis was conducted to evaluate the predictive value of WBCHR for in-hospital MACE after reperfusion therapy in STEMI patients.Results The levels of fasting blood glucose,uric acid,creatinine,white blood cell count,neutrophil count,high-sensitivity C-reactive protein(hs-CRP),D-dimer,and WBCHR were significantly higher in the MACE group than in the non-MACE group,while red blood cell count,hemoglobin,hematocrit,and left ventricular ejection fraction were lower(P＜0.05).No significant differences were observed in age,gender,smoking history,hypertension history,diabetes history,door-to-wire(D2W)time,total cholesterol,triglycerides,and the number of diseased vessels be-tween the two groups(P＞0.05).Multivariate Logistic regression analysis revealed that elevated u-ric acid levels(OR=1.005;95％CI,1.002 to 1.009;P=0.004),decreased hemoglobin concen-tration(OR=0.964;95％CI,0.941 to 0.988;P=0.003),increased hs-CRP levels(OR=1.032;95％CI,1.009 to 1.056;P=0.007),and increased WBCHR(OR=1.455;95％CI,1.295 to 1.635;P＜0.001)were independent risk factors for in-hospital MACE after reperfusion therapy in STEMI patients.ROC curve analysis showed that the area under the curve of WBCHR for predicting in-hospital MACE after reperfusion therapy in STEMI patients was 0.855(95％CI,0.796 to 0.914,P＜0.001),with a sensitivity of 63.8％and a specificity of 99.6％.Conclusion WBCHR is an independent influencing factors of in-hospital MACE after reperfusion therapy in STEMI patients and has a high predictive value for in-hospital MACE in these patients.
万方数据
维普
