Objective To explore the clinical characteristics and prognostic outcomes of patients with acute myocardial infarction complicated by Coronavirus Disease 2019(COVID-19).Methods A retrospective study was conducted in 76 patients with acute myocardial infarction.Based on the pres-ence of COVID-19,they were divided into the COVID-19 group(n=42)and the control group(n=34).General clinical conditions,laboratory examination indicators,interventional treatment charac-teristics,incidence of complications during hospitalization and prognosis were compared between the two groups.Independent influencing factors for coronary thrombotic lesions in acute myocardial infarc-tion patients were analyzed.Results The diastolic blood pressure,left ventricular ejection fraction and lymphocyte count were significantly lower,while lipoprotein a,C-reactive protein,serum ferritin,fi-brinogen,and D-dimer were significantly higher in the COVID-19 group than those in the control group(P＜0.05).The proportions of coronary thrombotic lesions,baseline TIMI flow of grade 0 to 1,thrombus burden of grade 4 to 5,use of GP Ⅱb/Ⅲa inhibitors and thrombus aspiration in the COVID-19 group were significantly higher than those in the control group(P＜0.05).Multivariate Logistic regres-sion analysis revealed that COVID-19 and increased D-dimer were independent risk factors for coronary thrombotic lesions in acute myocardial infarction patients.The average length of hospital stay was sig-nificantly longer in the COVID-19 group than that in the control group(P＜0.05).A 6-month follow-up showed that the incidence of major adverse cardiac events(MACEs)was significantly higher in the COVID-19 group than that in the control group(P=0.014).Conclusion Patients with acute myocardial infarction complicated by COVID-19 exhibit a higher coronary thrombus load and have a poor prognosis.
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