Changes of serum homocysteine,lactate dehydrogenase and interleukin-17 levels in acute leukemia and their significance
Objective To analyze the correlations of serum homocysteine(Hcy),lactate dehy-drogenase(LDH)and interleukin-17(IL-17)levels with the clinical characteristics and short-term efficacy of acute leukemia(AL).Methods Ninety-five AL patients were selected as study group,and another 95 healthy volunteers during the same period were chosen as control group.The general information and levels of Hcy,LDH and IL-17 were compared between the two groups.The serum levels of Hcy,LDH and IL-17 were compared among patients with different clinical characteristics in the study group.The relationship between serum Hcy,LDH and IL-17 levels and the clinical features of AL was analyzed.The serum levels of Hey,LDH and IL-17 before and after treatment,as well as their change values(△ indicating the absolute value of the change in the corresponding indicator be-fore and after treatment)were compared among AL patients.The correlation of the changes in serum Hcy,LDH and IL-17 levels with the short-term efficacy of AL was analyzed.Results The serum levels of Hey,LDH,and IL-17 in the study group[(14.36±3.24)µmol/L,(591.42±113.85)U/L and(9.64±3.01)pg/mL,respectively]were significantly higher than those in the control group[(9.75±2.08)μmol/L,(120.81±20.64)U/L and(4.08±1.25)pg/mL,respectively](P＜0.05).In the study group,patients at high risk of stratification had significantly higher serum levels of Hcy,LDH and IL-17[(15.83±3.10)μmol/L,(636.19±110.54)U/L and(10.62±2.96)pg/mL,respectively]compared to patients at low and medium risk[(12.58±2.71)µmol/L,(537.28±95.68)U/L and(8.45±2.29)pg/mL,respectively].Patients with extramedullary infiltration had significantly higher serum levels of Hcy,LDH,and IL-17[(16.12±3.15)μmol/L,(647.59±115.46)U/L and(11.05±3.04)pg/mL,respectively]compared to patients without extramedul-lary infiltration[(13.38±2.89)µmol/L,(560.11±97.25)U/L and(8.85±2.65)pg/mL,re-spectively](P＜0.05).There was a positive correlation of serum levels of Hey,LDH,and IL-17 with the risk stratification and extramedullary infiltration of AL in the study group(P＜0.05).Pa-tients with poor treatment response in the study group had significantly higher serum levels of Hcy,LDH and IL-17 before and after treatment compared to patients with a good treatment response,and△ Hcy,△ LDH and △ IL-17 were significantly smaller than those of patients with a good treatment response(P＜0.05).There were positive correlations between △Hcy,△LDH and △IL-17 and the short-term efficacy of AL in the study group(P＜0.05).Conclusion The serum levels of Hcy,LDH and IL-17 are positively correlated with the risk stratification and extramedullary infiltra-tion of AL,and the changes in these indicators before and after treatment are positively correlated with the short-term efficacy of AL.
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