Expression and significance of soluble receptor for advanced glycation end products and interleukin-36γ in serum of patients with Hashimoto's thyroiditis
Objective To explore expression and significance in serum levels of soluble receptor for advanced glycation end products(sRAGE)and interleukin-36(IL-36)in patients with Hashimoto's thyroiditis(HT).Methods A total of 180 individuals suspected of HT were enrolled as study sub-jects and divided into HT group(n=137)and non-HT group(n=43)based on final diagnostic out-comes.Within the HT group,patients were further divided into serum immunoglobulin G4(IgG4)-related HT group(IgG4≥135 mg/dL)and non-IgG4-related HT group(IgG4＜135 mg/dL)accord-ing to serum IgG4 levels.Serum levels of sRAGE and IL-36γ were measured in all subjects using en-zyme-linked immunosorbent assay(ELISA).Receiver operating characteristic(ROC)curves were used to analyze the diagnostic value of serum sRAGE and IL-36γ levels forHT and its IgG4 pheno-type.Results Serum sRAGE levels were significantly lower in the HT group compared to the non-HT group,while serum IL-36γ levels were significantly higher(P＜0.001).Patients in the IgG4-related HT group had significantly lower serum sRAGE levels and higher serum IL-36γ levels com-pared to those in the non-IgG4-related HT group(P＜0.001).ROC curve analysis revealed that the combined diagnosis of serum sRAGE and IL-36γ for HT had an area under the curve(AUC)of 0.900(95％CI,0.846 to 0.939),demonstrating significantly higher diagnostic efficiency than either indicator(P＜0.05).For the IgG 4 phenotype in HT patients,the combined AUC of serum sRAGE and IL-36γ was 0.897(95％CI,0.934 to 0.943),which also significantly higher than individual indicator(P＜0.05).Conclusion Serum sRAGE levels are significantly decreased,while serum I L-36γ levels are significantly increased in HT patients.Combined detection of serum sRAGE and IL-36y levels can effectively diagnose HT and assess the IgG4 phenotype.
Hashimoto's thyroiditissoluble receptor for advanced glycation end productsinterleukin-36γimmunoglobulin G4 typing
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维普
