Relationships of 25-hydroxyvitamin D,human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients
Objective To investigate the correlations of levels of 25-hydroxyvitamin D[25(OH)D],human β-defencin-2(HBD-2)and insulin-like growth factor 1(IGF-1)in peripheral blood with dis-ease severity of acne patients.Methods A total of 128 patients with acne vulgaris were included in the acne group and 128 healthy subjects were included in the control group.The levels of 25(OH)D,HBD-2 and IGF-1 in peripheral blood of two groups were detected.The relationships between the lev-els of 25(OH)D,HBD-2,IGF-1 in peripheral blood and the disease severity of acne patients were an-alyzed.The relationships between 25(OH)D,HBD-2 and IGF-1 levels in peripheral blood of acne pa-tients were analyzed.The diagnostic value of 25(OH)D,HBD-2 and IGF-1 levels in severe acne was evaluated using receiver operating characteristic(ROC)curves.Results The level of 25(OH)D in peripheral blood of the acne group was significantly lower than that of the control group,and the level of IGF-1 was significantly higher than that of the control group(P＜0.05).There was no significant difference in HBD-2 levels between the two groups(P＞0.05).In the acne group,with the aggrava-tion of disease severity,the level of 25(OH)D in peripheral blood was significantly decreased,and the level of IGF-1 was significantly increased(P＜0.05).The level of 25(OH)D in peripheral blood of acne patients was negatively correlated with the level of IGF-1 and the severity of the disease(r=-0.509,-0.586,P＜0.05),and the level of IGF-1 was positively correlated with the severity of the disease(r=0.547,P＜0.05).HBD-2 level was not correlated with 25(OH)D,IGF-1 level and disease severity(P＞0.05).The sensitivity of peripheral blood 25(OH)D level and IGF-1 level in evaluating severity acne was 94.12％,61.26％,respectively,and the specificity was 70.59％,77.48％,respectively.The sensitivity and specificity of combined evaluation of severe acne were 90.91％and 71.43％,respectively.Conclusion The level of 25(OH)D is decreased and the level of IGF-1 is increased in patients with acne,which is related to the severity of the disease.The combination of 25(OH)D and IGF-1 levels has a better efficacy in evaluating severity acne.
acne25-hydroxyvitamin Dhuman β-defensin-2insulin-like growth factor 1severity of disease
万方数据
维普
