Effect of semaglutide combined with metformin on ratio of serum apolipoprotein B to apolipoprotein A1,omentin-1 and fibroblast growth factor-21 in patients with type 2 diabetes mellitus
Objective To investigate the effect of semaglutide combined with metformin on the ratio of apolipoprotein B to apolipoprotein A1(ApoB/ApoA1),omentin-1 and fibroblast growth factor-21(FGF-21)levels in patients with type 2 diabetes mellitus(T2DM).Methods A total of 86 pa-tients with T2DM were selected as research objects and randomly divided into control group(treated with metformin)and observation group(treated with semaglutide and metformin).The fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,blood lipid indicators,insulin au-toantibody(IAA),insulin resistance index(HOMA-IR),pancreatic β-cell function index(HOMA-β),ApoB/ApoA1,omentin-1,and FGF-21 levels before and after treatment were compared between the two groups.The occurrence of adverse reactions in both groups was also compared.Results After treatment,the fasting blood glucose,2-hour postprandial blood glucose,and glycated hemoglobin lev-els in the observation group were significantly lower than those in the control group(P＜0.05).After treatment,the total cholesterol,triglycerides,and low-density lipoprotein cholesterol levels in the ob-servation group were significantly lower than those in the control group,while the high-density lipoprotein cholesterol level was significantly higher than that in the control group(P＜0.05).After treatment,the HOMA-IR and IAA in the observation group were significantly lower than those in the control group,while the HO M A-β was significantly higher than that in the control group(P＜0.05).After treatment,the serum omentin-1 level in the observation group was significantly higher than that in the control group,while the ApoB/ApoA1 and FGF-21 levels were significantly lower than those in the control group(P＜0.05).In the control group,there were 1 case of diarrhea and 2 cases of constipation,with a total incidence of adverse reactions of 6.98％;in the observation group,there were 1 case of hypoglycemia and 1 case of diarrhea,with a total incidence of adverse reactions of 4.65％;there was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Semaglutide combined with metformin can effectively control blood glucose and blood lipid levels in patients with T2DM,increase omentin-1 level,and reduce ApoB/ApoA1 and FGF-21 levels.
万方数据
维普
