Breast cancer(BRCA)is the most common malignant tumor in the world and the leading cause of death in female patients.In addition,early detection of BRCA by conventional screening methods(mammography,CT,ultrasound)is limited to a certain extent,and liquid biopsy technology has become increasingly advantageous for the early diagnosis of BRCA patients.Circulat-ing Tumor DNA(ctDNA)is a partially free extracellular DNA present in body fluids.The ctDNA is a new idea for screening novel tumor markers based on liquid biopsy technology and helps in clinical decision-making for early breast cancer.In this paper,we discussed the biological properties of ctD-NA,detection methods,and its application in the diagnosis and treatment of early BRCA,and we al-so look forward to the future research direction of ctDNA.
关键词
早期乳腺癌/循环肿瘤DNA/液体活检/生物标志物
Key words
early breast cancer/circulating tumor DNA/liquid biopsy/biomarkers
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