Association between symptom burden and depression after hepatectomy in hepatocellular carcinoma patients:a moderated mediation model
Objective To explore the mechanisms associated with symptom burden and depres-sion in hepatocellular carcinoma patients after hepatectomy.Methods A total of 230 hospitalized pa-tients with hepatocellular carcinoma who were underwent hepatectomy for the first time were selected as study subjects.A self-administered General Information Questionnaire,MD Anderson Symptom In-ventory,Patient Health Questionnaire,Connor-Davidson Resilience Scale,and Pittsburgh Sleep Quality Index were used to investigate sociodemographic,sociodemographic data,symptom burden,depression,psychological resilience,and sleep quality of postoperative hepatocellular carcinoma pa-tients.Pearson correlation analysis was used to identify specific associations among variables.The mediating and moderating effects of psychological resilience and sleep quality between symptom bur-den and depression were analyzed using the Process.Results Psychological resilience partially me-diated the association between symptom burden and depression(β=-0.137,SE=0.084,95％CI,-0.243 to-0.082),with the mediating effect accounting for 44.08％of the total effect,and the interaction term between symptom burden and sleep quality had predictive value for psychological re-silience(β=-0.014,t=-6.209,P＜0.001).Conclusion Postoperative symptom burden in hepatocellular carcinoma patients can play a role in depression through psychological resilience,where the effect of symptom burden on psychological resilience is moderated by sleep quality.Clinical staff should take reducing patients'postoperative symptom burden and improving psychological elastic-ity with sleep quality as important goals and develop appropriate nursing interventions to reduce the risk of depression in patients.
国家科技期刊平台
NSTL
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