缺氧诱导因子1α在肝细胞癌靶点治疗中的研究进展
Research progress on hypoxia-inducible factor 1αin targeted therapy for hepatocellular carcinoma
黄丽恒 1林洪升 2邓增富 2杨利 2李明芬3
作者信息
- 1. 广西中医药大学第一附属医院,输血科,广西南宁,530023;广西中医药大学,广西南宁,530200
- 2. 广西中医药大学第一附属医院,检验科,广西南宁,530023
- 3. 广西中医药大学,广西南宁,530200;广西中医药大学第一附属医院,检验科,广西南宁,530023
- 折叠
摘要
肝细胞癌(HCC)关键基因和调控分子为靶点的新型治疗方案逐步在临床中开展.缺氧诱导因子(HIF)作为肝癌细胞适应缺氧微环境的关键因子,其介导改变了许多基因的转录.HIF拥有广泛的靶基因,可通过调控各种信号通路促使癌细胞发生代谢重编程、血管生成、侵袭转移、免疫逃逸等.缺氧诱导因子1α(HIF-1α)作为HIF家族的主要成员,可为HCC的治疗挖掘潜在靶点提供新思路和新见解.
Abstract
Novel therapeutic approaches targeting key genes and regulatory molecules of hepato-cellular carcinoma(HCC)have gradually been carried out in clinical practice.Hypoxia-inducible factor(HIF),as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvi-ronment,mediates changes in the transcription of many genes.HIF has a wide range of target genes and can promote metabolic reprogramming,angiogenesis,invasion and metastasis,and immune es-cape of cancer cells by regulating various signaling pathways.Hypoxia-inducible factor 1α(HIF-1α),as the main member of the HIF family,can provide new ideas and insights for exploring potential tar-gets for HCC treatment.
关键词
缺氧诱导因子/肝细胞癌/缺氧诱导因子1αKey words
hypoxia-inducible factor/hepatocellular carcinoma/hypoxia-inducible factor 1 α引用本文复制引用
基金项目
广西自然科学基金资助项目(2023GXNSFAA026278)
出版年
2024
国家科技期刊平台
NSTL
万方数据