摘要
目的 探讨维持性血液透析(MHD)患者血清细胞分裂周期蛋白42(CDC-42)、β2微球蛋白(β2-MG)、腓骨蛋白1(FBLN1)水平与腹主动脉钙化(AAC)的相关性.方法 收集74例MHD患者的一般资料和生化指标,根据腹主动脉钙化评分(AACs)将患者分为无和轻度AAC组36例和中重度AAC组38例.比较2组血清CDC-42、β2-MG、FBLN1水平,采用多因素Logistic回归分析探讨MHD患者发生AAC的危险因素.结果 中重度AAC组透析龄、血磷、全段甲状旁腺激素(iPTH)、CDC-42、β2-MG、FBLN1水平高于无和轻度AAC组,差异有统计学意义(P＜0.05).MHD患者AAC与血磷、iPTH、CDC-42、β2-MG、FBLN1、透析龄呈正相关(P＜0.05).高CDC-42、β2-MG、FBLN1水平及长透析龄是MHD患者发生AAC的独立危险因素(P＜0.05).结论 血清CDC-42、β2-MG、FBLN1水平与MHD患者AAC呈正相关,高CDC-42、β2-MG、FBLN1水平及长透析龄是MHD患者发生AAC的独立危险因素.
Abstract
Objective To investigate the correlations of serum cell division cycle 42(CDC-42),β2-microglobulin(β2-MG)and fibulin 1(FBLN1)levels with abdominal aortic calcification(AAC)in patients with maintenance hemodialysis(MHD).Methods General information and bio-chemical indicators of 74 MHD patients were collected,and they were divided into no to mild AAC group(n=36)and moderate to severe AAC group(n=38)based on the Abdominal Aortic Calcifi-cation Score(AACs).Serum levels of CDC-42,β2-MG and FBLN1 were compared between the two groups,and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients.Results The dialysis vintage,serum phosphorus,intact parathyroid hormone(iPTH),CDC-42,β2-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group(P＜0.05).AAC in MHD patients was positively cor-related with serum phosphorus,iPTH,CDC-42,β2-MG,FBLN1,and dialysis vintage(P＜0.05).High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage were independent risk fac-tors for AAC in MHD patients(P＜0.05).Conclusion Serum CDC-42,β2-MG and FBLN1 levels are positively correlated with AAC in MHD patients.High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.
基金项目
安徽省自然科学基金项目(2308085QH255)
安徽医科大学校科研基金项目(2018xkj031)
国家科技期刊平台
NSTL
万方数据