Relationships of urinary liver-type fatty acid-binding protein and serum galectin-3 with early renal dysfunction in gout patients
Objective To investigate the relationships of urinary liver-type fatty acid-binding pro-tein(L-FABP)and serum galectin-3(Gal-3)with early renal dysfunction in gout patients.Methods A total of 124 gout patients in the hospital from January 2022 to December 2023 were selected as gout group,and they were divided into non-renal injury group with 42 cases and early renal injury group with 82 cases according to the urinary albumin-to-creatinine ratio(UACR).Additionally,40 healthy volunteers with physical examinations in the hospital in the same period were selected as control group.The levels of urea nitrogen,creatinine,cystatin C,urinary L-FABP,and serum Gal-3 were measured in all participants.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of urinary L-FABP and serum Gal-3 for early renal dysfunction in gout patients.Results The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the gout group were significantly higher than those in the control group(P＜0.05).The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the early renal injury group were significantly higher than those in the non-renal injury group(P＜0.05).Pearson analysis showed that urinary L-FABP level in gout patients was significantly positively correlated with UACR,cystatin C,and serum Gal-3(P＜0.05),and serum Gal-3 level in gout pa-tients was significantly positively correlated with UACR,cystatin C,and urinary L-FABP(P＜0.05).ROC curve analysis indicated that urinary L-FABP and serum Gal-3 had high diagnostic values for assessing early renal dysfunction in gout patients,with areas under the curve(AUCs)of 0.804(95％CI,0.726 to 0.882)and 0.781(95％CI,0.697 to 0.866)respectively.The AUC for the combination of urinary L-FABP and serum Gal-3 was 0.923(95％CI,0.874 to 0.972).Conclu-sion The levels of urinary L-FABP and serum Gal-3 are abnormally elevated in gout patients,and their expression levels are closely related to early renal dysfunction.The combination of urinary L-FABP and serum Gal-3 has a high diagnostic value for early renal dysfunction in gout patients.
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