Impact of Coronavirus Disease 2019 on long-term renal function in patients with chronic kidney disease undergoing no renal replacement therapy
Objective To investigate the impact of Coronavirus Disease 2019(COVID-19)on long-term renal function in patients with chronic kidney disease(CKD)who received no renal re-placement therapy.Methods Thirty-nine CKD patients with an estimated glomerular filtration rate(eGFR)＜60 mL/(min·1.73 m2)at the time of COVID-19 diagnosis,admitted to Guizhou Aero-space Hospital from December 2022 to March 2023,were enrolled in the COVID-19 group.Addition-ally,40 CKD patients without COVID-19 from September to December 2021,were included in control group.Changes in eGFR were compared between the two groups,and the temporal trend of eGFR in the COVID-19 group was analyzed using a mixed-effects linear model.Results No statistically sig-nificant differences were observed in eGFR levels at baseline,1-and 3-month of follow-up between the COVID-19 and control groups(P＞0.05).However,at 1 year of follow-up,the eGFR level in the COVID-19 group was significantly lower than that in the control group(P＜0.05).The mixed-effects linear model analysis revealed a decrease in eGFR by 1.84 mL/(min·1.73 m2)within 1 year of COVID-19 onset in the COVID-19 group,which inclined 4.62％from baseline,with the most significant decline(7.45％)observed among diabetic patients.Conclusion Patients with CKD who have not undergone renal replacement therapy experience a substantial decline in eGFR and worsened renal function within 1 year of COVID-19,necessitating close long-term renal function mo-nitoring and timely interventions.
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