Therapeutic effect of allogeneic hematopoietic stem cell transplantation on acute myeloid leukemia and influencing factors of survival prognosis
Objective To observe the therapeutic effect of allogeneic hematopoietic stem cell transplantation(allo-HSCT)on acute myeloid leukemia(AML)and analyze the influencing factors of survival prognosis.Methods The clinical data of 32 AML patients who underwent allo-HSCT treat-ment were retrospectively analyzed.The hematopoietic reconstitution,occurrence of graft-versus-host disease(GVHD),survival status,recurrence,and transplantation-related mortality(TRM)of pa-tients were observed,and the influencing factors of survival prognosis were analyzed.Results All 32 AML patients who underwent allo-HSCT achieved granulocyte reconstitution,with a time range of 10 to 26 days and a median time of 11.0 days.Granulocyte-macrophage lineage reconstitution was achieved in 30 patients,with a time range of 10 to 54 days and a median time of 13.5 days.Among the 30 evaluable patients,10 developed acute GVHD(with incidence rate of 33.33％)and 10 developed chronic GVHD(incidence rate of 33.33％).Up to May 31,2023,the follow-up time ranged from 2 to 28 months,with a median follow-up time of 14.5 months.Of the 30 patients,28 survived(25 pa-tients were in disease-free survival status),and 2 died.Multivariate Cox regression analysis showed that age＞35 years(P=0.035,HR=2.021)and recurrence after transplantation(P=0.021,HR=2.546)were independent risk factors of patients'survival prognosis.Among 30 patients,5 relapsed,with a time range of 6 to 24 months and a median time of 9.0 months.Of 5 relapsed patients,2 died(non-TRM).Conclusion Allo-HSCT is an effective treatment for AML.Age＞35 years and recur-rence after transplantation are independent risk factors of patients'survival prognosis.
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