Clinicopathological analysis of three follicular lymphoma cases with anaplastic morphology
Objective To investigate the clinicopathological features,immunophenotype,molec-ular characteristics,differential diagnosis,and prognosis of follicular lymphoma with anaplastic mor-phology.Methods Immunohistochemical EnVision two-step method was used to detect the expres-sions of CD20,PAX5,CD10,BCL6,MUM-1,BCL2,CD30,Ki-67,and other markers in three ca-ses of follicular lymphoma with anaplastic morphology.In situ fluorescence hybridization was used to detect BCL2,BCL6,and MYC gene translocations.The clinicopathological features,diagnosis,differ-ential diagnosis,and prognosis of follicular lymphoma with anaplastic morphology were analyzed.Re-sults The follicular lymphoma with anaplastic morphology in this study exhibited high-grade features and occurred in middle-aged and elderly patients.Immunohistochemically,the tumors expressed panB markers,were negative for CD10,positive for BCL6,mostly positive for MUM1,and positive for c-myc expression.However,no BCL6 or MYC gene translocations were detected.Conclusion Follicu-lar lymphoma with anaplastic morphology is uncommon and mostly presents as high-grade follicular lymphoma.It is important to correctly recognize its various morphological variants.
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