血清肿瘤坏死因子α刺激基因6蛋白和Ⅹ Ⅵ型胶原蛋白预测溃疡性结肠炎患者预后的价值
Values of serum tumor necrosis factor-α stimulated gene 6 protein and type Ⅹ Ⅵ collagen in predicting prognosis of patients with ulcerative colitis
孟利军 1张兰芳 1秦蕾 1李文静 1申培君 1陈旭 1郭晓鹤1
作者信息
- 1. 新乡医学院第一附属医院消化内科,河南新乡,453100
- 折叠
摘要
目的 分析血清肿瘤坏死因子α刺激基因6蛋白(TSG-6)、Ⅹ Ⅵ型胶原蛋白(col-16)预测溃疡性结肠炎(UC)患者预后的价值.方法 选取160例UC患者为UC组,另选取160例志愿者为对照组,比较2组血清TSG-6、col-16水平.参照改良Mayo评分标准将UC组患者分为轻度组(n=63)、中度组(n=52)、重度组(n=45),比较3组血清TSG-6、col-16水平.根据肠镜复查结果将UC组患者分为预后良好组(n=121)和预后不良组(n=39),比较2组血清TSG-6、col-16水平.采用Spearman相关性分析法探讨血清TSG-6、col-16与改良Mayo评分的相关性;采用Logistic回归分析法探讨血清TSG-6、col-16对UC组患者预后的影响;采用受试者工作特征(ROC)曲线评估血清TSG-6、col-16预测UC组患者预后的价值.结果 UC组血清TSG-6、col-16水平高于对照组,差异有统计学意义(P＜0.01).中度组、重度组血清TSG-6、col-16水平高于轻度组,重度组血清TSG-6、col-16水平高于中度组,差异均有统计学意义(P＜0.01).预后不良组血清TSG-6、col-16水平高于预后良好组,差异有统计学意义(P＜0.01).Spearman相关性分析结果显示血清TSG-6、col-16与改良Mayo评分均呈正相关性(r=0.691,P＜0.05;r=0.635,P＜0.05).Logistic分析结果显示血清TSG-6、col-16均是预后不良的危险因素(P＜0.001).ROC曲线分析显示,血清TSG-6、col-16预测UC组患者预后不良的曲线下面积分别为0.773、0.765.结论 UC患者血清TSG-6、col-16呈异常升高状态,且与患者病情严重程度及预后存在一定的相关性,可作为预后不良的预测指标.
Abstract
Objective To analyze the values of serum tumor necrosis factor-α stimulated gene 6 protein(TSG-6)and type Ⅹ Ⅵ collagen(col-16)in predicting the prognosis of patients with ulcera-tive colitis(UC).Methods A total of 160 patients with UC were enrolled as UC group,another 160 volunteers were selected as control group,and the levels of serum TSG-6 and col-16 were compared between the two groups.According to the modified Mayo scoring criteria,patients in the UC group were divided into mild group(n=63),moderate group(n=52),and severe group(n=45),and the levels of serum TSG-6 and col-16 were compared among the three groups.Based on the colonosco-py follow-up results,patients in the UC group were divided into good prognosis group(n=121)and poor prognosis group(n=39),and the levels of serum TSG-6 and col-16 were compared between the two groups.Spearman correlation analysis was used to explore the correlations of serum TSG-6 and col-16 with the modified Mayo score.Logistic regression analysis was used to investigate the impact of ser-um TSG-6 and col-16 on the prognosis of patients in the UC group.Receiver operating characteristic(ROC)curve was used to assess the values of serum TSG-6 and col-16 in predicting the prognosis of pa-tients in the UC group.Results The levels of serum TSG-6 and col-16 in the UC group were significantly higher than those in the control group(P＜0.01).The levels of serum TSG-6 and col-16 in the moderate and severe groups were significantly higher than those in the mild group,and the levels of serum TSG-6 and col-16 in the severe group were significantly higher than those in the moderate group(P＜0.01).The levels of serum TSG-6 and col-16 in the poor prognosis group were signifi-cantly higher than those in the good prognosis group(P＜0.01).Spearman correlation analysis showedthat serum TSG-6 and col-16 were positively correlated with the modified Mayo score(r=0.691,P＜0.05;r=0.635,P＜0.05).Logistic analysis results showed that serum TSG-6 and col-16 were risk factors for poor prognosis(P＜0.001).ROC curve analysis showed that the areas under the curve for predicting poor prognosis in patients with UC were 0.773 and 0.765 for serum TSG-6 and col-16,respectively.Conclusion The levels of serum TSG-6 and col-16 are abnormally elevated in patients with UC,and there is a certain correlation of the two indexes with the severity and prognosis of disease,and the two indexes can be used as predictors of poor prognosis.
关键词
肿瘤坏死因子α刺激基因6蛋白/Ⅹ/Ⅵ型胶原蛋白/溃疡性结肠炎/预后/相关性/预测价值Key words
tumor necrosis factor-α stimulated gene 6 protein/type Ⅹ Ⅵ collagen/ulcera-tive colitis/prognosis/correlation/predictive value引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据