Values of serum tumor necrosis factor-α stimulated gene 6 protein and type Ⅹ Ⅵ collagen in predicting prognosis of patients with ulcerative colitis
Objective To analyze the values of serum tumor necrosis factor-α stimulated gene 6 protein(TSG-6)and type Ⅹ Ⅵ collagen(col-16)in predicting the prognosis of patients with ulcera-tive colitis(UC).Methods A total of 160 patients with UC were enrolled as UC group,another 160 volunteers were selected as control group,and the levels of serum TSG-6 and col-16 were compared between the two groups.According to the modified Mayo scoring criteria,patients in the UC group were divided into mild group(n=63),moderate group(n=52),and severe group(n=45),and the levels of serum TSG-6 and col-16 were compared among the three groups.Based on the colonosco-py follow-up results,patients in the UC group were divided into good prognosis group(n=121)and poor prognosis group(n=39),and the levels of serum TSG-6 and col-16 were compared between the two groups.Spearman correlation analysis was used to explore the correlations of serum TSG-6 and col-16 with the modified Mayo score.Logistic regression analysis was used to investigate the impact of ser-um TSG-6 and col-16 on the prognosis of patients in the UC group.Receiver operating characteristic(ROC)curve was used to assess the values of serum TSG-6 and col-16 in predicting the prognosis of pa-tients in the UC group.Results The levels of serum TSG-6 and col-16 in the UC group were significantly higher than those in the control group(P＜0.01).The levels of serum TSG-6 and col-16 in the moderate and severe groups were significantly higher than those in the mild group,and the levels of serum TSG-6 and col-16 in the severe group were significantly higher than those in the moderate group(P＜0.01).The levels of serum TSG-6 and col-16 in the poor prognosis group were signifi-cantly higher than those in the good prognosis group(P＜0.01).Spearman correlation analysis showedthat serum TSG-6 and col-16 were positively correlated with the modified Mayo score(r=0.691,P＜0.05;r=0.635,P＜0.05).Logistic analysis results showed that serum TSG-6 and col-16 were risk factors for poor prognosis(P＜0.001).ROC curve analysis showed that the areas under the curve for predicting poor prognosis in patients with UC were 0.773 and 0.765 for serum TSG-6 and col-16,respectively.Conclusion The levels of serum TSG-6 and col-16 are abnormally elevated in patients with UC,and there is a certain correlation of the two indexes with the severity and prognosis of disease,and the two indexes can be used as predictors of poor prognosis.
国家科技期刊平台
NSTL
万方数据
