目的 探讨体检人群幽门螺杆菌(Hp)感染情况及其与高血压、糖脂代谢的关联性。方法 选取287例体检者作为研究对象。根据14 C-尿素呼气试验筛查Hp感染结果，将体检者分为Hp阳性组(n=125)和Hp阴性组(n=162)。比较2组基线资料和糖脂代谢水平。采用多因素Logistic回归分析法筛选体检人群Hp感染的影响因素。结果 287例体检者Hp感染率为43。55％。Hp阳性组的经常外出就餐率为34。40％，高于Hp阴性组的13。58％，差异有统计学意义(P＜0。05)。Hp阳性组的空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)高于Hp阴性组，高密度脂蛋白胆固醇(HDL-C)低于Hp阴性组，差异有统计学意义(P＜0。05)。多因素Logistic回归分析显示，外出就餐(OR=1。401，95％CI:1。142～1。717)、FBG(OR=3。865，95％CI:1。810～8。253)、TC(OR=4。141，95％CI:2。025～8。469)、TG(OR=4。259，95％CI:2。128～8。524)、HDL-C(OR=4。125，95％CI:1。989～8。552)是体检人群 Hp 感染的影响因素(P＜0。05)，HOMA-IR 与体检人群Hp感染无关(P＞0。05)。结论 体检人群Hp感染率较高，且Hp感染与糖脂代谢异常存在显著相关性，但与高血压无相关性。
Helicobacter pylori infection in physical examination population and its correlations with hypertension,glucose and lipid metabolism
Objective To investigate the infection of Helicobacter pylori(Hp)and its relation-ships with hypertension,glucose and lipid metabolism in the physical examination population.Meth-ods A total of 287 individuals undergoing physical examinations were selected as study subjects.Based on the results of 14C-urea breath test screening for Hp infection,participants were divided into Hp-positive group(n=125)and Hp-negative group(n=162).Baseline characteristics and glyco-lipid metabolism levels were compared between the two groups.Multivariate Logistic regression analy-sis was used to identify factors influencing Hp infection in the study population.Results The Hp in-fection rate among the 287 individuals was 43.55％.The frequency of eating out in the Hp-positive group was 34.40％,which was significantly higher than 13.58％in the Hp-negative group(P＜0.05).Fasting blood glucose(FBG),insulin resistance index(HOMA-IR),total cholesterol(TC)and triacylglycerol(TG)in the HP-positive group were significantly higher,and high-density lipopro-tein cholesterol(HDL-C)was significantly lower than that in the Hp-negative group(P＜0.05).Mult-ivariate Logistic regression analysis revealed that eating out(OR=1.401,95％CI,1.142 to 1.717),FBG(OR=3.865,95％CI,1.810 to 8.253),TC(OR=4.141,95％CI,2.025 to 8.469),TG(OR=4.259,95％CI,2.128 to 8.524)and HDL-C(OR=4.125,95％CI,1.989 to 8.552)were factors influencing Hp infection in the study population(P＜0.05).HOMA-IR was not associated with Hp infection in the study population(P＞0.05).Conclusion The prevalence of Hp infection is high among individuals undergoing physical examinations,and Hp infection has significant association with abnormalities in glycolipid metabolism,but no association with hypertension.
万方数据
维普
