Helicobacter pylori infection in physical examination population and its correlations with hypertension,glucose and lipid metabolism
高燕 1张丹 1李倩 1张俊波 1刘柳 1朱亚男 1郭姗姗1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 中国人民解放军火箭军特色医学中心全科医学科,北京,100088
折叠
摘要
目的 探讨体检人群幽门螺杆菌(Hp)感染情况及其与高血压、糖脂代谢的关联性.方法 选取287例体检者作为研究对象.根据14 C-尿素呼气试验筛查Hp感染结果,将体检者分为Hp阳性组(n=125)和Hp阴性组(n=162).比较2组基线资料和糖脂代谢水平.采用多因素Logistic回归分析法筛选体检人群Hp感染的影响因素.结果 287例体检者Hp感染率为43.55％.Hp阳性组的经常外出就餐率为34.40％,高于Hp阴性组的13.58％,差异有统计学意义(P＜0.05).Hp阳性组的空腹血糖(FBG)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)高于Hp阴性组,高密度脂蛋白胆固醇(HDL-C)低于Hp阴性组,差异有统计学意义(P＜0.05).多因素Logistic回归分析显示,外出就餐(OR=1.401,95％CI:1.142～1.717)、FBG(OR=3.865,95％CI:1.810～8.253)、TC(OR=4.141,95％CI:2.025～8.469)、TG(OR=4.259,95％CI:2.128～8.524)、HDL-C(OR=4.125,95％CI:1.989～8.552)是体检人群 Hp 感染的影响因素(P＜0.05),HOMA-IR 与体检人群Hp感染无关(P＞0.05).结论 体检人群Hp感染率较高,且Hp感染与糖脂代谢异常存在显著相关性,但与高血压无相关性.
Abstract
Objective To investigate the infection of Helicobacter pylori(Hp)and its relation-ships with hypertension,glucose and lipid metabolism in the physical examination population.Meth-ods A total of 287 individuals undergoing physical examinations were selected as study subjects.Based on the results of 14C-urea breath test screening for Hp infection,participants were divided into Hp-positive group(n=125)and Hp-negative group(n=162).Baseline characteristics and glyco-lipid metabolism levels were compared between the two groups.Multivariate Logistic regression analy-sis was used to identify factors influencing Hp infection in the study population.Results The Hp in-fection rate among the 287 individuals was 43.55％.The frequency of eating out in the Hp-positive group was 34.40％,which was significantly higher than 13.58％in the Hp-negative group(P＜0.05).Fasting blood glucose(FBG),insulin resistance index(HOMA-IR),total cholesterol(TC)and triacylglycerol(TG)in the HP-positive group were significantly higher,and high-density lipopro-tein cholesterol(HDL-C)was significantly lower than that in the Hp-negative group(P＜0.05).Mult-ivariate Logistic regression analysis revealed that eating out(OR=1.401,95％CI,1.142 to 1.717),FBG(OR=3.865,95％CI,1.810 to 8.253),TC(OR=4.141,95％CI,2.025 to 8.469),TG(OR=4.259,95％CI,2.128 to 8.524)and HDL-C(OR=4.125,95％CI,1.989 to 8.552)were factors influencing Hp infection in the study population(P＜0.05).HOMA-IR was not associated with Hp infection in the study population(P＞0.05).Conclusion The prevalence of Hp infection is high among individuals undergoing physical examinations,and Hp infection has significant association with abnormalities in glycolipid metabolism,but no association with hypertension.
维普
万方数据