Objective To optimize the flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology.Methods The extraction yields of mor-roniside and loganin,as well as the yield of dry extract,were used as evaluation indices.The rotation speed,liquid-solid ratio,and extraction time were selected as the investigation factors.Based on pre-liminary experiments,combined with Box-Behnken design-response surface methodology,the flash ex-traction process of Huangyu Shenshu Granules was studied and optimized.Results The optimal con-dition for the flash extraction of Huangyu Shenshu Granules were taking water as the extraction solvent,with a rotation speed of 4,560 r/min,a liquid-solid ratio of 23 mL/g,and an extraction time of 85 s.Conclusion The flash extraction process established based on Box-Behnken design-response surface methodology is rapid and efficient,and suitable for the subsequent industrialization development of Huangyu Shenshu Granules.
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