Diagnostic efficacy of dynamic contrast-enhanced magnetic resonance imaging combined with diffusion-weighted imaging for prostate cancer
Objective To analyze the diagnostic efficacy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion-weighted imaging(DWI)in prostate cancer(PCa).Methods A total of 94 patients with prostate diseases were selected as study subjects,and divided into PCa group(n=41)and benign prostatic hyperplasia(BPH)group(n=53).The gen-eral information of the two groups was compared.The diagnostic efficacy of DCE-MRI and DWI exam-ination parameters in PCa and their correlation with serum prostate-specific antigen(PSA)were ana-lyzed.Results There were statistically significant differences in total prostate-specific antigen(tPSA),free prostate-specific antigen(fPSA)/tPSA,prostate volume(V),prostate-specific antigen density(PSAD),plasma volume fraction(Vp),reflux rate constant(Kep),volume transfer constant(Ktrans),extracellular extravascular volume fraction(Ve)and apparent diffusion coefficient(ADC)between the two groups(P＜0.05).The area under the curve for the combined prediction of PCa u-sing DCE-MRI and DWI examination parameters was 0.924,which was greater than that for individu-al predictors or the combination of DCE-MRI examination parameters.Ktrans,Kep and Ve were positive-ly correlated with tPSA and negatively correlated with fPSA/tPSA,while Vp and ADC were negatively correlated with tPSA and positively correlated with fPSA/tPSA(P＜0.05).Conclusion The com-bination of DCE-MRI and DWI has high diagnostic value for predicting PCa,and Ktrans,Kep,Ve,Vp and ADC have certain correlations with tPSA and fPSA/tPSA.
dynamic contrast-enhanced magnetic resonance imagingdiffusion-weighted ima-gingprostate cancerprostate-specific antigen
万方数据
维普
