Objective To investigate the application effect of fiberoptic bronchoscopy and alveolar lavage therapy in the diagnosis and treatment of recurrent wheezing diseases in children.Methods A total of 151 children with recurrent wheezing diseases were enrolled,and divided into control group(n=84)and study group(n=67)based on different diagnostic and therapeutic methods.The control group received conventional diagnosis and treatment,while the study group underwent fiberoptic bron-choscopy combined with alveolar lavage therapy.The time to resolution of symptoms and length of hos-pital stay were compared between the two groups.Additionally,lung function[forced expiratory vol-ume in 1 second(FEV1),FEV1/forced vital capacity(FEV1/FVC)and peak expiratory flow(PEF)],exhaled nitric oxide(FeNO),serum inflammatory mediator levels[C-reactive protein(CRP),procalcitonin(PCT)and white blood cell(WBC)count]and clinical efficacy were com-pared.Results The absence time of wheezing and pulmonary rales and hospital stay in the study group were significantly shorter than those in the control group(P＜0.05).After treatment,FEV1,FEV1/FVC and PEF in two groups were significantly higher than before treatment,and the study group was significantly higher than the control group(P＜0.05).After treatment,FeNO,CRP,PCT and WBC in two groups were significantly lower than before treatment,and the study group was significantly lower than the control group(P＜0.05).The total effective rate of the study group was 94.03％,which was significantly higher than 77.38％of the control group(P＜0.05).Conclusion Fiber-optic bronchoscopy and alveolar lavage are effective in the diagnosis and treatment of recurrent asth-matic diseases in children,which can effectively relieve symptoms,shorten hospital stay,and im-prove lung function,FeNO and serum inflammatory mediators.
关键词
纤维支气管镜检查/肺泡灌洗治疗/儿童反复喘息性疾病/血清炎症介质/肺功能
Key words
fiberoptic bronchoscopy/alveolar lavage therapy/recurrent wheezing diseases in children/serum inflammatory mediators/lung function
维普
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