Changes and clinical significance of serum levels of soluble CD163 and interleukin-38 in patients with advanced plaque psoriasis
Objective To analyze the changes and clinical significance of serum levels of soluble CD163(sCD163)and interleukin-38(IL-38)in patients with plaque psoriasis(PsV).Methods Eighty patients with PsV were selected as study subjects(PsV group),and divided into mild PsV group(n=30),moderate PsV group(n=21),and severe PsV group(n=29)based on the Psoriasis Area and Severity Index(PASI)score.A total of 80 healthy subjects were selected as control group.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum levels of sCD163 and IL-38 in all participants.Spearman's correlation analysis was employed to assess the correlations of serum levels of sCD163 and IL-38 with the severity of PsV.Results The level of sCD163 in the PsV group was significantly higher,and the level of IL-38 was significantly lower than that in the control group(P＜0.001).Serum sCD163 levels in PsV patients increased significantly with the increase of disease severity(F=10.207,P＜0.001).Serum IL-38 levels in PsV patients decreased significant-ly with the increase of disease severity(F=55.116,P＜0.001).The expression level of sCD163 in PsV patients was positively correlated with PASI score(r=0.549,P=0.013);the expression level of IL-38 in PsV patients was negatively correlated with PASI score(r=-0.601,P=0.007).Re-ceiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)of sCD163 and IL-38 in the diagnosis of moderate and severe PsV were 0.835 and 0.856,respectively,and the AUC of the combined detection of SCD163 and IL-38 was 0.935,which was higher than that of the single detection(Zcombined-sCD163=2.021,Zcombined-IL-38=2.331,P＜0.05).Conclusion Serum sCD163 levels are significantly elevated,while IL-38 levels are significantly reduced in PsV pa-tients,both closely correlating with disease severity.The combined detection of sCD163 and IL-38 has high diagnostic value for moderate to severe PsV.
plaque psoriasisadvanced stagesoluble CD163interleukin-38Psoriasis Ar-ea and Severity Index
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