摘要
目的 探讨血清胰岛素样生长因子-1(IGF-1)水平在原发性甲状腺功能亢进症诊疗中的价值.方法 选取150例原发性甲状腺功能亢进症患者(甲亢组)和85例甲状腺功能减退症患者(甲减组)为研究对象.选取同期60例健康体检者为对照组.检测3组血清IGF-1、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、三碘甲状腺原氨酸(T3)和总甲状腺素(T4)水平.采用酶联免疫吸附试验检测3组血清内脂素水平.采用多因素Logistic回归分析法筛选原发性甲亢发病的危险因素.结果 甲亢组患者的IGF-1、FT3、FT4、T3、T4水平高于甲减组、对照组,TSH水平低于甲减组、对照组,差异有统计学意义(P＜0.05).甲亢组患者的TPOAb水平、内脂素水平高于对照组,低于甲减组,差异有统计学意义(P＜0.05).原发性甲状腺功能亢进症患者治疗前和治疗后3个月的血清IGF-1水平分别为(60.11±7.23)、(30.23±3.22)μg/L,差异有统计学意义(t=8.436,P＜0.001).血清 FT3、FT4、T3、T4、TPOAb、IGF-1与内脂素水平升高及血清TSH水平降低为原发性甲状腺功能亢进症发病的危险因素(P＜0.05).结论 血清IGF-1水平与甲状腺功能密切相关,其或可作为原发性甲状腺功能亢进症诊断和疗效监测的重要参考指标.
Abstract
Objective To explore the value of serum insulin-like growth factor-1(IGF-1)levels in diagnosis and treatment of primary hyperthyroidism.Methods 150 patients with primary hyper-thyroidism(hyperthyroidism group)and 85 patients with hypothyroidism(hypothyroidism group)were selected as study subjects.During the same period,60 healthy individuals were selected as con-trol group.The levels of serum IGF-1,thyroid peroxidase antibody(TPOAb),thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),triiodothyronine(T3)and to-tal thyroxine(T4)were measured in the three groups.The serum visfatin levels in the three groups were detected using an enzyme-linked immunosorbent assay.Multifactor Logistic regression analysis was used to screen for risk factors of primary hyperthyroidism.Results The levels of IGF-1,FT3,FT4,T3 and T4 in the hyperthyroidism group were significantly higher than those in the hypothyroid-ism and control groups,while TSH levels were significantly lower(P＜0.05).TPOAb and visfatin levels in the hyperthyroidism group were significantly higher than those in the control group,but signifi-cantly lower than those in the hypothyroidism group(P＜0.05).The serum IGF-1 levels in patients with primary hyperthyroidism before and after 3 months of treatment were(60.11±7.23)and(30.23±3.22)μg/L,respectively,showing a statistically significant difference(t=8.436,P＜0.001).Serum FT3,FT4,T3,T4,TPOAb,IGF-1 and visfatin levels increased and serum TSH levels de-creased as risk factors for primary hyperthyroidism(P＜0.05).Conclusion The level of serum IGF-1 is closely related to thyroid function and may serve as an important reference indicator for the diagnosis and monitoring of the efficacy of primary hyperthyroidism treatment.
维普
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