Value of serum insulin-like growth factor-1 levels in diagnosis and treatment of primary hyperthyroidism
Objective To explore the value of serum insulin-like growth factor-1(IGF-1)levels in diagnosis and treatment of primary hyperthyroidism.Methods 150 patients with primary hyper-thyroidism(hyperthyroidism group)and 85 patients with hypothyroidism(hypothyroidism group)were selected as study subjects.During the same period,60 healthy individuals were selected as con-trol group.The levels of serum IGF-1,thyroid peroxidase antibody(TPOAb),thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),triiodothyronine(T3)and to-tal thyroxine(T4)were measured in the three groups.The serum visfatin levels in the three groups were detected using an enzyme-linked immunosorbent assay.Multifactor Logistic regression analysis was used to screen for risk factors of primary hyperthyroidism.Results The levels of IGF-1,FT3,FT4,T3 and T4 in the hyperthyroidism group were significantly higher than those in the hypothyroid-ism and control groups,while TSH levels were significantly lower(P＜0.05).TPOAb and visfatin levels in the hyperthyroidism group were significantly higher than those in the control group,but signifi-cantly lower than those in the hypothyroidism group(P＜0.05).The serum IGF-1 levels in patients with primary hyperthyroidism before and after 3 months of treatment were(60.11±7.23)and(30.23±3.22)μg/L,respectively,showing a statistically significant difference(t=8.436,P＜0.001).Serum FT3,FT4,T3,T4,TPOAb,IGF-1 and visfatin levels increased and serum TSH levels de-creased as risk factors for primary hyperthyroidism(P＜0.05).Conclusion The level of serum IGF-1 is closely related to thyroid function and may serve as an important reference indicator for the diagnosis and monitoring of the efficacy of primary hyperthyroidism treatment.
万方数据
维普
