As an intelligent flexible material with multi-field coupling characteristics,the preparation technology,performance characterization,and structural application of hydrogels have been rapidly developed.Based on a detailed analysis of the constitutive theory and structural design of hydrogels,this paper proposes the basic methods and paradigms of computational multi-field coupling mechanics of hydrogels.At the microscopic scale,a coarse-grained molecular dynamics model of hydrogel has been developed.The coarse-grained force field was determined by using a machine learning method.At the macroscale,based on the recently developed constitutive models for isotropic hydrogel incorporating the effects of chain entanglements and anisotropic hydrogel reinforced by fibers,a coupled finite element method is presented to investigate the chemo-mechanical coupling behavior of the designed intelligent structures of hydrogels.It is pointed out that computational multi-field coupled mechanics will become the main analysis method for hydrogel structures,which contributes to the property design and engineering application of this kind of intelligent flexible materials.