Based on BioWin6.0,a model was built and validated for a large wastewater treatment plant with AAO process in northern China.The simulation research was carried out for energy reduction and drug consumption optimization,and the recommended operating parameters and drug consumption op-timization scheme in winter were verified.The results showed that COD,NH4+-N and TP were stably better than the Class Ⅳ standard of Surface water environmental quality standard(GB 3838-2002)(except TN)after optimization.Energy consumption can be saved by 1 755 kW·h/d after optimization,which was 11.3%lower than before;the unit consumption of PAC decreased from 40 mg/L to 19 mg/L,decreasing 52.03%,and the effect of energy reduction and drug consumption optimization was remarkable.