Palladium-catalyzed cascade imidoylation/carbonylation to construct isoquinolinone tetracyclic compounds
Using 1,3-bis(2-iodoaryl)propane-2-amines as substrates,a palladium-catalyzed sequen-tial insertion of isocyanide and carbon monoxide to construct isoquinolinone skeletons has been devel-oped.Compared with isoelectronic isocyanide counterparts,the migratory insertion of isocyanide to Ar-Pd(Ⅱ)is still prefer to carbon monoxide although carbon monoxide exists in large excess in the reaction.Followed by carbon monoxide insertion and finally reductive elimination,the corresponding isoquinolinone tetracyclic compounds were obtained.The reaction conditions were mild and the yields are up to 85％.The product was correctly identified by1H NMR,13C NMR and high-resolution mass spectrometry.
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