Research progress on mechanical properties of natural polymer based corneal repair materials
Due to the large number of blind individuals and the shortage of donor corneas available for transplantation,artificial corneas have gradually become a research hotspot.However,artificial cor-neas often experience implant tearing due to insufficient mechanical properties.In order to solve this problem,researchers at home and abroad have tried to improve the mechanical properties of corneal repair materials by a series of research work.This paper summarizes the progress relating to the me-chanical properties of four common natural polymer-based corneal repair materials,namely collagen,gelatin,silk fibroin,and chitosan.The results show that physical methods such as photo-crosslinking and thermal crosslinking,chemical methods such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide(EDC)/N-hydroxysuccinimide(NHS)crosslinking,genipine or glutaraldehyde crosslinking and other composite methods can significantly improve the mechanical properties of corneal materials,but these methods still have some shortcomings.Therefore,further development of high-quality artificial corne-as is crucial.It is hoped that the article can provide some reference and ideas for the study of impro-ving the mechanical properties of corneal repair materials through summarization.
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