New indocyanine green-loaded reduction responsive polymeric micelles for enhanced cancer photodynamic therapy
In this study,disulfide bonded methoxypolyethylene glycol-cholesterol conjugates mPEG5000-SS-CH and mPEG2000-SS-CH were synthesized.The two types of IR820-loaded micelles,IR820@mPEG5000-SS-CH and IR820@mPEG2000-SS-CH,which might significantly improve the stability of IR820 in physiological environment,were prepared by solvent diffusion method.While vitro studies show that both mPEG5000-SS-CH and mPEG2000-SS-CH have reduction-responsive re-lease characteristics and good biocompatibility,IR820@mPEG2000-SS-CH displays enhanced cellular uptake and photodynamic killing effect on tumor cells as compared to free IR820 and IR820@mPEG5000-SS-CH.The study suggests that IR820@mPEG2000-SS-CH could be a new choice with superior stability and cancer photodynamic therapeutic effect to IR820.
new indocyanine greenphotodynamic therapypolyethylene glycolcholesterolmicellesreduction responsiveness
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