Comparative Study of 3D-Printed Porous Titanium Alloy with Rod Designs of Three Different Geometric Structures for Orthopaedic Implantation

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外文摘要：Porous titanium alloy is currently widely used in clinical treatment of orthopaedic diseases for its lower elastic modulus and ability to integrate with bone tissue.At the micro-level,cells can respond to different geometries,and at the macro-level,the geometric design of implants will also affect the biological function of cells.In this study,three kinds of porous scaffolds with square,triangular and circle rod shapes were designed and 3D printed.This study observed the proliferation and differentia-tion of MC3T3-E1 cells during surface culture of the three types of scaffolds.It also evaluated the characteristics of the three scaffolds by means of compression tests and scanning electron microscopy to provide a reference for the design of porous titanium alloy implants for clinical applications.The trends of cell proliferation and gene expression between the three types of scaffolds were observed after treatment with two inhibitors.The results show that the square rod porous scaffolds have the best proliferative and osteogenic activities,and these findings may be due to differences in piezo-type mechanosensitive ion channel component 1(Piezo 1)and Yes-associated protein(YAP)expression caused by the macro-geometric topography.

外文关键词：

Porous titanium scaffoldsGeometric morphologyCell proliferationStructural design

作者：

Jiaxin Li、Haozhang Zhong、Bojun Cao、Zhaoyang Ran、Jia Tan、Liang Deng、Yongqiang Hao、Jinglong Yan

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作者单位：

Department of Orthopedics,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China

Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

Institute of Materials Modification and Modeling,Shanghai Jiao Tong University,Shanghai 200240,China

基金：

Shanghai Municipal Key Clinical Specialty-Biomedical Materials3-year Action Plan of Shen kang Development CentreHuangpu District Industrial Support FundShanghai Engineering Research Centre of Innovative Orthopedic Instruments and Personalized MedicineIndustry Standard Study on 3D Printing Personalized Titanium Alloy Pelvic Reconstruction Prosthesis

项目编号：

shslczdzk06701SHDC2020CR2019BXK202000919DZ225020021DZ2201500

出版年：

2024

DOI：

10.1007/s40195-023-01573-0

金属学报(英文版)

中国金属学会

金属学报(英文版)

CSTPCD

影响因子：0.77

ISSN：1006-7191

年,卷(期)：2024.37(1)

参考文献量48