老年人同型半胱氨酸水平与代谢综合征的相关性研究
Correlation between homocysteine level and risk of metabolic syndrome among the elderly
许敏锐 1史宏 2潘英姿 2强德仁 2孔晓玲 2石素逸 2宗菁 2杨佳成 2闫于飘 2张锡炳 2杨国英2
作者信息
- 1. 常州市武进区疾病预防控制中心,江苏常州 213100;常州市武进区前黄镇寨桥卫生院
- 2. 常州市武进区疾病预防控制中心,江苏常州 213100
- 折叠
摘要
目的 探讨≥65岁老年人同型半胱氨酸(homocysteine,Hcy)与代谢综合征及其组分的相关性.方法 研究对象来自2022年武进区≥65岁老年健康体检人群,健康体检内容包括问卷调查、体格检查和实验室检查.采用logistic回归分析血清Hcy与代谢综合征患病的相关性.结果 共纳入112 378人,平均年龄(72.66±5.62)岁,患代谢综合征44 014人(39.17％),Hcy水平为(14.42±8.56)μmol/L,高Hcy者34 744人(30.92％).随着血清Hcy水平的增加,代谢综合征及其各组分(除男性高血糖外)的患病率逐渐增加(P值均＜0.05).调整相关混杂因素后,与Hey四分位分组Q1组相比,男性Q2、Q3、Q4组患代谢综合征的 OR(95％CI)分别为 1.06(1.00～1.11)、1.11(1.05～1.16)、1.19(1.13～1.26);女性 Q2、Q3、Q4组患代谢综合征的OR(95％CI)分别为1.03(0.98～1.08)、1.13(1.07～1.18)、1.19(1.13～1.25).代谢综合征及其各组分(除高血糖和女性TG升高外)患病风险均随着Hey水平的升高而增加(P值均＜0.01).结论 ≥65岁老年人Hey水平与代谢综合征及其组分相关,老年人群应注意控制Hey水平,预防控制代谢综合征的发生.
Abstract
Objective To examine the correlation between homocysteine(Hey)level and risk of metabolic syndrome and its components among the elderly at ages of 65 years and older.Methods The elderly at ages of 65 years and older that received health examinations in Wujin District in 2022 were recruited,and health examinations included questionnaire surveys,physical examinations and laboratory tests.The association of serum Hey level with the risk of metabolic syndrome was evaluated with the logistic regression a-nalysis.Results A total of 112 378 elderly residents were enrolled,with a mean age of(72.66±5.62)years.The prevalence of met-abolic syndrome was 39.17％,and the subjects had a mean Hey level of(14.42±8.56)µmol/L,including 34 744 residents a high Hcy level(30.92％).The prevalence of metabolic syndrome and its components(except hyperglycemia among men)gradually in-creased with serum Hcy level(all P values＜0.05).After adjustment for confounding factors,the odds ratios(ORs)of metabolic syn-drome were 1.06[95％confidential interval(CI):(1.00,1.11)],1.11[95％CI:(1.05,1.16)]and 1.19[95％CI:(1.13,1.26)]among men and 1.03[95％CI:(0.98,1.08)],1.13[95％CI:(1.07,1.18)]and 1.19[95％CI:(1.13,1.25)]among women with the second,third and fourth quartiles of Hcy versus the first quartile.The risk of metabolic syndrome and its components(except hyper-glycemia and elevated triglyceridemia levels among women)increased with serum Hey level(all P values＜0.01).Conclusions The Hcy level correlates with the risk of metabolic syndrome and its components among the elderly at ages of 65 years and older.The Hey levels are needed to be controlled among the elderly to prevent the development of metabolic syndrome.
关键词
老年人/同型半胱氨酸/代谢综合征Key words
Elderly/Homocysteine/Metabolic syndrome引用本文复制引用
基金项目
江苏省预防医学科研面上项目(Ym2023014)
常州市卫生健康委科技项目(QN202382)
常州市卫生健康高层次人才培养工程项目(十四五)(2022CZBJ112)
出版年
2024
NETL
NSTL
万方数据