摘要
目的 研究某品牌灵芝破壁孢子粉的安全性.方法 采用急性毒性试验、3项遗传毒性试验和30 d喂养试验评价灵芝破壁孢子粉的安全性.结果 该品牌灵芝破壁孢子粉对小鼠急性经口 MTD值＞15 000 mg/kgb.wt,属无毒级;3项遗传毒性试验均为阴性结果;30d喂养期间,不同剂量的灵芝破壁孢子粉对大鼠的体重、食物利用率、主要脏体、血液学和血生化指标均产生显著影响(P值均＜0.05);试验动物组织病理学均未见显著改变.结论 试验条件下,该品牌灵芝破壁孢子粉的安全性良好.
Abstract
Objective To assess the safety of a wall-broken Ganoderma lucidum spore powder.Methods The safety of a wall-broken Ganoderma lucidum spore powder was evaluated through acute toxicity test,three genetic toxicity tests and 30-day feeding test.Results The oral maximum tolerated dose of this wall-broken Ganoderma lucidum spore powder was＞15 000 mg/kg body weight in mice,belonging to the non-toxic grade,and all three genetic toxicity tests were negative.During the 30-day feeding period,the dose of this wall-broken Ganoderma lucidum spore powder had significant impacts on the body weight,food utilization rate,main visceral body,and hematological and blood biochemical parameters of rats(all P values＜0.05).In addition,no remarkable changes were seen in the pathology of animal tissues.Conclusions The wall-broken Ganoderma lucidum spore powder has a high safety under experimental conditions.
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