Safety assessment of a wall-broken Ganoderma lucidum spore powder
Objective To assess the safety of a wall-broken Ganoderma lucidum spore powder.Methods The safety of a wall-broken Ganoderma lucidum spore powder was evaluated through acute toxicity test,three genetic toxicity tests and 30-day feeding test.Results The oral maximum tolerated dose of this wall-broken Ganoderma lucidum spore powder was＞15 000 mg/kg body weight in mice,belonging to the non-toxic grade,and all three genetic toxicity tests were negative.During the 30-day feeding period,the dose of this wall-broken Ganoderma lucidum spore powder had significant impacts on the body weight,food utilization rate,main visceral body,and hematological and blood biochemical parameters of rats(all P values＜0.05).In addition,no remarkable changes were seen in the pathology of animal tissues.Conclusions The wall-broken Ganoderma lucidum spore powder has a high safety under experimental conditions.
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