HPV感染导致宫颈癌发生的协同因素研究进展
Progress of research on co-factors for cervical cancer caused by human papilloma virus infection
姜来 1詹亚惠 1朱晓燕 1蔡如明1
作者信息
- 1. 苏州市疾病预防控制中心,江苏苏州 215004
- 折叠
摘要
宫颈癌作为严重影响女性健康的危害因素备受全世界关注.宫颈癌的发生与遗传、生活方式及生物因素等有关,其中人乳头瘤病毒(human papilloma virus,HPV)尤其是高危型HPV持续感染宫颈细胞被认为是宫颈癌发生、发展的重要因素,而HPV持续感染人群最终并不是全部发展成宫颈癌,如存在高危HPV持续感染伴阴道、宫颈微环境菌群紊乱等多因素协同作用,可能会发展为宫颈癌.本文就HPV感染导致宫颈癌发生的协同因素(HPV型别,E6、E7蛋白表达,阴道、宫颈微环境等)进行综述.
Abstract
As a great threat to woman health,cervical cancer has attracted worldwide attention.Previous studies have demonstra-ted that the development of cervical cancer is associated with genetic factors,life style and biological factors,and persistent infection with human papilloma virus(HPV),notably high-risk HPV,is accepted as a major contributor to cervical cancer development and progression.Nevertheless,persistent HPV infection is not the only determinant of cervical cancer,which requires a synergistic effect with multiple factors,such as persistent high-risk PHV infection complicated by microflora imbalance in vaginal and cervical microen-vironments.This review describes an overview of HPV infection and other co-factors,including HPV type,E6 and E7 protein expres-sion,and vaginal and cervical microenvironments.
关键词
人乳头瘤病毒/宫颈癌/协同因素Key words
Human papilloma virus(HPV)/Cervical cancer/Co-factor引用本文复制引用
基金项目
苏州市科教兴卫青年科技项目(KJXW2019052)
苏州市科技发展计划(第二十八批)(SKY2022068)
出版年
2024
NETL
NSTL
万方数据