Progress of researches on structural design of mRNA vaccines and their applications in disease prevention and control
With advances in biological science and technology and pharmaceutical technology,mRNA vaccines have shown high potential to fight against cancers and infectious diseases.Unlike conventional vaccines,mRNA vaccines have advantages of simple de-sign,rapid production,and high safety and efficacy;however,they suffer from problems of poor stability and easy degradation by nucle-ase in the body.Development of mRNA vaccines has underwent rapid developments in the context of global COVID-19 pandemic.Effec-tive carrier development,mRNA immunogenicity control,reduced manufacturing costs,and increased transport stability and effectiveness lead to widespread applications of mRNA vaccines in clinical practices.The review summarizes the advances in structural design of mR-NA vaccines and their applications in disease prevention and control.
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