Etiological characteristics and risk factors of multidrug-resistant organisms among the elderly with pulmonary infections and at ages of over 60 years in a hospital in Changzhou City
Objective To investigate the etiological characteristics and risk factors of multidrug-resistant organisms among the elderly with pulmonary infections and at ages of over 60 years in a hospital in Changzhou City.Methods The clinical data pertaining to the elderly patients with pulmonary infections and at ages of over 60 years admitted to Intensive Care Unit(ICU)and Department of Respiratory Medicine in a hospital in Changzhou City during the period between June 2019 and October 2022 were collected,and the pathogen distribution was analyzed.The risk factors of multidrug-resistant organisms(MDRO)infection in the lung were identified among the elderly patients using univariate analysis of variance and multivariate logistic regression analysis.Results A total of 1 464 elderly patients with pulmonary infections were enrolled,and the incidence of MDRO was 13.52％.A total of 309 MDRO isolates were found in specimens sampled from respiratory tract,which were mainly characterized as Pseudomonas aeruginosa,Klebsiella pneumoniae,Staphylococcus haemolyticus and S.aureus.Multivariate logistic regression analysis showed a 4.70-fold higher risk of MDRO infections a-mong long-term bedridden patients than among non-long-term bedridden patients[95％confidential interval(CI):(2.13,10.37),P＜0.01]and a 3.32-fold higher risk among patients with mechanical ventilation time of 7 days and longer than among those with me-chanical ventilation time of less than 7 days[95％CI:(1.41,7.79),P＜0.01].Conclusions Targeted interventions should be giv-en to the elderly patients with pulmonary infections with long-term bedridden procedures and long-term mechanical ventilation to reduce the risk of MDRO infection and improve the survival rate.
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