Prevalence and molecular epidemiology of hantavirus in rodents in Guangzhou City from 2021 to 2022
Objective To investigate the prevalence of hantavirus infections in rodents in Guangzhou City in recent years.Methods Rodents were captured from Guangzhou City from 2021 to 2022 and characterized.Rodent lung specimens were collected and tested for hantavirus nuclear acid,and positive lung specimens were subjected to sequencing.Results A total of 409 rodents were captured,and the prevalence of Seoul virus(SEOV)infection was 32.27％,without hantaan virus(HTNV)detected.The prevalence of SEOV infections was 36.39％in Rattus norvegicus,30.43％in Rattus flavipectus,12.50％in Mus musculus and 9.30％in Suncus muri-nus(x2=15.82,P＜0.05).SEOV was detected in rodents across 11 districts of Guangzhou City,with 8.57％to 51.72％prevalence of infections(x2=42.11,P＜0.05).Sequencing analysis and phylogenetic analysis of SEOV-positive specimens showed that SEOV isolates from Guangzhou City were clustered into the same clade,and shared a high homology with the SEOV sequences in 2017 and 2019,which all belonged to S3 subtype.Conclusions The high prevalence of SEOV infections in Guangzhou City may be strongly associated with the local transmission of hemorrhagic fever with renal syndrome in Guangzhou City.Persistent investigations of hantavirus infections in local rodents and viral genome are recommended in Guangzhou City.
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