摘要
目的 了解上海远郊农村≥60岁老年脑卒中高危人群同型半胱氨酸(Hcy)水平及影响因素,为预防脑卒中提供数据参考.方法 选择2023年脑卒中高危人群筛查项目中筛出的≥60岁高危人群,经体格检查、生化等检测后收集有效样本1 025人,对相关数据进行统计分析.结果 1 025人中检出高同型半胱氨酸(HHcy)577例,检出率为56.29％.多因素分析结果显示,男性(OR=4.631,95％CI:3.277～6.544)、高年龄[70～＜80 岁(OR=2.355,95％CI:1.740～3.187)和 ≥80 岁(OR=3.300,95％CI:1.791～6.080)]、肥胖或超重(OR=1.466,95％CI:1.078～1.993)、有高血压史(OR=1.545,95％CI:1.161～2.054)、血肌酐(CREA)升高(OR=5.452,95％CI:2.903～10.238)、血清尿素(Urea)升高(OR=2.158,95％CI:1.049～4.440)、血尿酸(UA)升高(OR=1.538,95％CI:1.085～2.179)是HHcy的危险因素(P值均＜0.05).结论 ≥60岁脑卒中高危人群中高同型半胱氨酸水平检出率较高,应针对重点人群开展有效干预.
Abstract
Objective To investigate the homocysteine levels and their influencing factors among high-risk populations for stroke at ages of 60 years and older in outer suburban rural areas of Shanghai Municipality,so as to provide insights into stroke prevention.Methods High-risk populations at ages of 60 years and older were screened from the 2023 Stroke High-risk Population Screening Program in 2023,and 1 025 eligible subjects were enrolled following physical examinations and biochemical detection.Patients'de-mographic and clinical features were statistically analyzed.Results High homocysteine levels were detected in 577 out of 1 025 partic-ipants,with a detection rate of 56.29％.Multivariate analysis identified man[odds ratio(OR)=4.631,95％CI:(3.277,6.544)],ad-vanced age[70 to＜80 years,OR=2.355,95％CI:(1.740,3.187);80 years and older,OR=3.300,95％CI:(1.791,6.080)],obe-sity or overweight[OR=1.466,95％CI:(1.078,1.993)],history of hypertension[OR=1.545,95％CI:(1.161,2.054)],elevated blood creatinine[OR=5.452,95％CI:(2.903,10.238)],elevated serum urea[OR=2.158,95％CI:(1.049,4.440)]and elevated blood uric acid[OR=1.538,95％CI:(1.085,2.179)]as risk factors of high homocysteine(all P values＜0.05).Conclusions The detection of high homocysteine is high among high-risk populations for stroke at ages of 60 years and older.Effective interventions targeting high-risk populations for stroke are recommended.
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