Homocysteine levels and their influencing factors among high-risk populations for stroke at ages of 60 years and older in outer suburban rural areas of Shanghai Municipality
Objective To investigate the homocysteine levels and their influencing factors among high-risk populations for stroke at ages of 60 years and older in outer suburban rural areas of Shanghai Municipality,so as to provide insights into stroke prevention.Methods High-risk populations at ages of 60 years and older were screened from the 2023 Stroke High-risk Population Screening Program in 2023,and 1 025 eligible subjects were enrolled following physical examinations and biochemical detection.Patients'de-mographic and clinical features were statistically analyzed.Results High homocysteine levels were detected in 577 out of 1 025 partic-ipants,with a detection rate of 56.29％.Multivariate analysis identified man[odds ratio(OR)=4.631,95％CI:(3.277,6.544)],ad-vanced age[70 to＜80 years,OR=2.355,95％CI:(1.740,3.187);80 years and older,OR=3.300,95％CI:(1.791,6.080)],obe-sity or overweight[OR=1.466,95％CI:(1.078,1.993)],history of hypertension[OR=1.545,95％CI:(1.161,2.054)],elevated blood creatinine[OR=5.452,95％CI:(2.903,10.238)],elevated serum urea[OR=2.158,95％CI:(1.049,4.440)]and elevated blood uric acid[OR=1.538,95％CI:(1.085,2.179)]as risk factors of high homocysteine(all P values＜0.05).Conclusions The detection of high homocysteine is high among high-risk populations for stroke at ages of 60 years and older.Effective interventions targeting high-risk populations for stroke are recommended.
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