Biotransformation and Anti-Tumor Activity of Matrine Derivatives
Objective: To prepare anti-tumor derivatives of matrine by biotransformation. Methods:Biotransformation technology was applied to prepare matrine derivatives, chromatography technologies were used to isolate the products, spectroscopy techniques were used to determine their structures and MTT method was used to test their cytotoxicity activity. Results: Five matrine derivatives were obtained, including 13-hydroxymatrine (1), 13,14-dihydroxymatrine (2), 12-hydroxymatrine (3), 13-carbonylmatrine (4) and 12-carbonylmatrine (5). Conclusion: Compounds 3-5 were new matrine derivatives and all the obtained compounds showed good anti-tumor activity in bioactivity test.
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万方数据
维普
